Genetics: Analysis and Principles 4th Edition by Robert Brooker

Exercise 15

The DNA-binding domain of each CREB protein subunit recognizes the sequence 5 -TGACGTCA-3 . As a matter of random chance, how often would you expect this sequence to occur in the human genome, which contains approximately 3 billion base pairs Actually, only a few dozen genes are activated by the CREB protein. Does the value of a few dozen agree with the number of random sites found in the human genome If the number of random sites in the human genome is much higher than a few dozen, provide at least one explanation why the CREB protein is not activating more than a few dozen genes.