Genetics: Analysis and Principles 4th Edition by Robert Brooker

Exercise 9

According to the methods described in Figure 21.5, can homologous recombination that results in gene replacement cause the integration of both the TK and Neo R genes Explain why or why not. Describe how the TK gene and Neo R gene are used in a selection scheme that favors gene replacement.
FIGURE 21.5 Producing a gene replacement in mice. The bottom of this figure shows a photograph of a chimeric mouse. Note the patches of black and white fur.