Genetics: Analysis and Principles 5th Edition by Robert Brooker

Exercise 16

Let's suppose that two different X-linked genes exist in mice, designated with the letters N and L. Gene N exists in a dominant, normal allele and in a recessive allele, n , that is lethal. Similarly, gene L exists in a dominant, normal allele and in a recessive allele, l , that is lethal. Heterozygous females are normal, but males that carry either recessive allele are born dead. Explain whether or not it would be possible to map the distance between these two genes by making crosses and analyzing the number of living and dead offspring. You may assume that you have strains of mice in which females are heterozygous for one or both genes.