Genetics: Analysis and Principles 5th Edition by Robert Brooker

Exercise 16

According to the methods described in Figure 21.5, can homologous recombination that results in gene replacement cause the integration of both the TK and Neo R genes Explain why or why not. Describe how the TK gene and Neo R gene are used in a selection scheme that favors gene replacement.FIGURE 21.5 Producing a gene replacement in mice. The bottom of this figure shows a photograph of a chimeric mouse. Note the patches of black and white fur.