Genetics: Analysis and Principles 5th Edition by Robert Brooker

Exercise 59

Lesch-Nyhan syndrome is due to a mutation in a gene that encodes a protein called hypoxanthine-guanine phosphoribosyltransferase (HPRT). HPRT is an enzyme that functions in purine metabolism. People afflicted with this syndrome have severe neurodegeneration and loss of motor control. The pedigree shown here contains several members with Lesch-Nyhan syndrome. Affected members are shown with black symbols. Based on this pedigree, does this syndrome appear to be an autosomal recessive, autosomal dominant, X-linked recessive, or X-linked dominant trait Explain your reasoning.