Human Heredity 11th Edition by Michael Cummings

Exercise 4

A new gene that causes an inherited form of retinal degeneration has been cloned from mice. This disease leads to blindness in affected individuals. As a researcher in a human vision laboratory, you want to see if a similar gene exists in humans (genes with similar sequences usually mean similar functions). With your knowledge of the Southern blot procedure, how would you go about doing this? Start with the isolation of human DNA.