Clinical Laboratory Hematology 3rd Edition by Shirlyn McKenzie, Lynne Williams

Exercise 5

Hancock, a 65-year-old white male, was seen in triage with complaints of fatigue, malaise, anorexia, and hemoptysis of recent onset. A complete blood count (CBC) was ordered and revealed anemia and a shift to the left in granulocytes. Hematopoietic cells showed dysplastic features.
Consider diagnostic probabilities and reflex testing that could provide differential diagnostic information.
The results of the CBC on Hancock were:
The neutrophilic cells show marked hyposegmentation and hypogranulation. Red blood cell (RBC) morphology includes anisocytosis and poikilocytosis, teardrop cells, ovalocytes, and schistocytes.
What features of the differential resemble chronic myeloid leukemia (CML)? What helps to distinguish this case from CML?