Biology 1st Edition by Jung Choi, Jean DeSaix, Yael Avissar, Vladimir Jurukovski, Robert Wise,Connie Rye, OpenStax

Exercise 12

Figure 7.11 Dinitrophenol (DNP) is an uncoupler that makes the inner mitochondrial membrane leaky to protons. It was used until 1938 as a weight-loss drug. What effect would you expect DNP to have on the change in pH across the inner mitochondrial membrane? Why do you think this might be an effective weightloss drug?