Biology 8th Edition by Kenneth Mason ,Jonathan Losos,Susan Singer,Peter Raven,George Johnson

Exercise 3

Regulation of the cell cycle is very complex and involves multiple proteins. In yeast, a complex of cdc2 and a mitotic cyclin is responsible for moving the cell past the G 2 /M checkpoint. The activity of the cyclin-dependent kinase cdc2 is inhibited when it is phosphorylated by the kinase, Wee-1. What would you predict would be the phenotype of a Wee-1 mutant yeast What other genes could be altered in a Wee-1 deficient mutant strain that would make the cells act normally