Essential Genetics 6th Edition by Daniel Hartl

Exercise 17

The male I-2 in the accompanying pedigree is affected with Huntington disease, a type of neuromuscular degeneration caused by a rare autosomal dominant mutation HD with complete penetrance. The wildtype, nonmutant allele is denoted hd. The woman II-1 is also affected. The RFLP alleles A and a yielding the bands in the gel are linked to the Huntington locus with a recombination frequency of 10 percent.
(a) Is the genotype of II-1 HD A/hd a or is it HD a/hd A ?
(b) Given the pattern of bands in the gel, what is the probability that III-1 will be affected?
(c) Given the pattern of bands in the gel, what is the probability that III-2 will be affected?