Molecular Biology of the Gene 7th Edition by Richard Losick, James Watson, Michael Levine, Tamara Baker, Alexander Gann

Exercise 10

You are studying the E. coli ZntR protein, a homolog to MerR, which responds to Zn(II) to regulate transcription of zntA, a gene that encodes a protein that aids in Zn(II) detoxification. What are two questions you would design your experiments to answer to support or refute the hypothesis that ZntR uses a mechanism similar to MerR to activate transcription of zntA ?