Genetics - Analysis and Principles 3rd Edition by Robert Brooker

Exercise 11

Let's suppose a DNA mutation changes the consensus sequence at the -35 location so that factor does not bind there as well. Explain how a mutation could inhibit the binding of factor to the DNA. Look at Figure 12.5 and describe two specific base substitutions you think would inhibit the binding of factor. Explain why you think your base substitutions would have this effect.