What Is Life? 2nd Edition by Jay Phelan

Exercise 17

The genetic disorder known as sickle-cell disease results in an altered form of the protein hemoglobin, which ultimately can affect the structure of red blood cells. A portion of the sequence of the normal hemoglobin allele is: CTG ACT CCT GAG GAG AAG TCT Individuals with the sickle-cell disorder have the following sequence: CTG ACT CCT GTG GAG AAG TCT Identify the type of mutation and explain how it would result in an altered (in this case non-functional) protein.