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Bioprocess Engineering 2nd Edition by Fikret Kargi,Michael Shuler
Edition 2ISBN: 9780130819086Bioprocess Engineering 2nd Edition by Fikret Kargi,Michael Shuler
Edition 2ISBN: 9780130819086 Exercise 11
A biochemical engineer has determined in her lab that the optimal productivity of a valuable an-
tibiotic is achieved when the carbon nutrient, in this case molasses, is metered into the fermenter
at a rate proportional to the growth rate. However, she cannot implement her discovery in the an-
tibiotic plant, since there is no reliable way to measure the growth rate (dX/dt) or biomass con-
centration (X) during the course of the fermentation. It is suggested that an oxygen analyzer be
installed on the plant fermenters so that the OUR (oxygen uptake rate, g/l-h) may be measured.
a. Derive expressions that may be used to estimate X and dX/dt from OUR and time data,
assuming that a simple yield and maintenance model may be used to describe the rate of
oxygen consumption by the culture.
b. Calculate values for the yield
![A biochemical engineer has determined in her lab that the optimal productivity of a valuable an- tibiotic is achieved when the carbon nutrient, in this case molasses, is metered into the fermenter at a rate proportional to the growth rate. However, she cannot implement her discovery in the an- tibiotic plant, since there is no reliable way to measure the growth rate (dX/dt) or biomass con- centration (X) during the course of the fermentation. It is suggested that an oxygen analyzer be installed on the plant fermenters so that the OUR (oxygen uptake rate, g/l-h) may be measured. a. Derive expressions that may be used to estimate X and dX/dt from OUR and time data, assuming that a simple yield and maintenance model may be used to describe the rate of oxygen consumption by the culture. b. Calculate values for the yield and maintenance parameters from the follow- ing data: [Courtesy of D. Zabriskie from Collected Coursework Problems in Biochemical Engineering, com- piled by H. W. Blanch for 1977 Am. Soc. Eng. Educ. Summer School.]](https://d2lvgg3v3hfg70.cloudfront.net/SM1185/11ec73a8_1d52_8538_b96d_8539dff288a5_SM1185_00.jpg)
and maintenance
![A biochemical engineer has determined in her lab that the optimal productivity of a valuable an- tibiotic is achieved when the carbon nutrient, in this case molasses, is metered into the fermenter at a rate proportional to the growth rate. However, she cannot implement her discovery in the an- tibiotic plant, since there is no reliable way to measure the growth rate (dX/dt) or biomass con- centration (X) during the course of the fermentation. It is suggested that an oxygen analyzer be installed on the plant fermenters so that the OUR (oxygen uptake rate, g/l-h) may be measured. a. Derive expressions that may be used to estimate X and dX/dt from OUR and time data, assuming that a simple yield and maintenance model may be used to describe the rate of oxygen consumption by the culture. b. Calculate values for the yield and maintenance parameters from the follow- ing data: [Courtesy of D. Zabriskie from Collected Coursework Problems in Biochemical Engineering, com- piled by H. W. Blanch for 1977 Am. Soc. Eng. Educ. Summer School.]](https://d2lvgg3v3hfg70.cloudfront.net/SM1185/11ec73a8_1d52_8539_b96d_6d8a8c8dce7a_SM1185_00.jpg)
parameters from the follow-
ing data:
![A biochemical engineer has determined in her lab that the optimal productivity of a valuable an- tibiotic is achieved when the carbon nutrient, in this case molasses, is metered into the fermenter at a rate proportional to the growth rate. However, she cannot implement her discovery in the an- tibiotic plant, since there is no reliable way to measure the growth rate (dX/dt) or biomass con- centration (X) during the course of the fermentation. It is suggested that an oxygen analyzer be installed on the plant fermenters so that the OUR (oxygen uptake rate, g/l-h) may be measured. a. Derive expressions that may be used to estimate X and dX/dt from OUR and time data, assuming that a simple yield and maintenance model may be used to describe the rate of oxygen consumption by the culture. b. Calculate values for the yield and maintenance parameters from the follow- ing data: [Courtesy of D. Zabriskie from Collected Coursework Problems in Biochemical Engineering, com- piled by H. W. Blanch for 1977 Am. Soc. Eng. Educ. Summer School.]](https://d2lvgg3v3hfg70.cloudfront.net/SM1185/11ec73a8_1d52_853a_b96d_cde88efb723a_SM1185_00.jpg)
[Courtesy of D. Zabriskie from "Collected Coursework Problems in Biochemical Engineering," com-
piled by H. W. Blanch for 1977 Am. Soc. Eng. Educ. Summer School.]
tibiotic is achieved when the carbon nutrient, in this case molasses, is metered into the fermenter
at a rate proportional to the growth rate. However, she cannot implement her discovery in the an-
tibiotic plant, since there is no reliable way to measure the growth rate (dX/dt) or biomass con-
centration (X) during the course of the fermentation. It is suggested that an oxygen analyzer be
installed on the plant fermenters so that the OUR (oxygen uptake rate, g/l-h) may be measured.
a. Derive expressions that may be used to estimate X and dX/dt from OUR and time data,
assuming that a simple yield and maintenance model may be used to describe the rate of
oxygen consumption by the culture.
b. Calculate values for the yield
and maintenance parameters from the follow-ing data:
[Courtesy of D. Zabriskie from "Collected Coursework Problems in Biochemical Engineering," com-
piled by H. W. Blanch for 1977 Am. Soc. Eng. Educ. Summer School.]
Explanation
Verified
Verified
An engineer in biochemical procedures ha...
Bioprocess Engineering 2nd Edition by Fikret Kargi,Michael Shuler
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