Question 1

When administering mechlorethamine (Mustargen),the nurse should avoid which of the following?&#10;A) Dilution&#10;B) Contact with the skin&#10;C) Intravenous use&#10;D) Reconstitution&#10;

Accepted Answer

Mechlorethamine is a cytotoxic medication used in chemotherapy. It should not be in contact with the skin as it can cause severe and painful blistering, and even death. Dilution, intravenous use, and reconstitution are all necessary steps for administering the medication safely and effectively.

Question 2

The nurse notes that a client receiving which of the following chemotherapy drugs is being treated with an agent that is a nitrosourea?&#10;A) Busulfan (Myleran)&#10;B) Floxuridine (FUDR)&#10;C) Cisplatin (Platinol)&#10;D) Carmustine (BiCNU)&#10;

Accepted Answer

Carmustine (BiCNU) is a nitrosourea chemotherapy drug used in the treatment of various cancers, including brain cancer and lymphoma. Busulfan (Myleran) is an alkylating agent, Floxuridine (FUDR) is an antimetabolite, and Cisplatin (Platinol) is a platinum-containing compound.

Question 3

The nurse would monitor the results of which of the following laboratory tests to detect the most common toxic effects of cisplatin (Platinol)? A) Vitamin B₆ B) Creatinine clearance C) Cholesterol D) Iron binding capacity

Accepted Answer

Creatinine clearance is the laboratory test of choice for monitoring toxic effects of cisplatin as it assesses kidney function, which is one of the main organs affected by cisplatin toxicity. Vitamin B, cholesterol, and iron binding capacity are not relevant laboratory tests for detecting cisplatin toxicity.

Question 4

The nurse recognizes that which of the following drugs being given to a client with cancer is an antimetabolite?&#10;A) Cyclophosphamide (Cytoxan)&#10;B) Fludarabine (Fludara)&#10;C) Daunorubicin (Cerubidine)&#10;D) Vinblastine (Velban)&#10;

Accepted Answer

Fludarabine is an antimetabolite drug that interferes with DNA synthesis and inhibits the growth and replication of cancer cells. Cyclophosphamide (A) is an alkylating agent that works by forming cross-links between strands of DNA to prevent cell division. Daunorubicin (C) is an anthracycline that works by binding to DNA and inhibiting the activity of topoisomerase II, an enzyme necessary for DNA replication. Vinblastine (D) is a mitotic inhibitor that blocks the formation of microtubules, preventing cell division.

Question 5

The nurse assesses that a client who is receiving cisplatin (Platinol)as chemotherapy is at increased risk for which of the following conditions?&#10;A) Hyperreflexia&#10;B) Tinnitus&#10;C) Polyuria&#10;D) Leukocytosis&#10;

Accepted Answer

Cisplatin (Platinol) can cause ototoxicity, which may result in tinnitus. It is not associated with hyperreflexia, polyuria, or leukocytosis.

Question 6

The nurse is aware that classifications of chemotherapy agents include which of the following?&#10;A) Antimetabolites and tumor antagonists&#10;B) Alkylating agents and antibiotics&#10;C) Miotic inhibitors and hormones&#10;D) Antihormones and acidifying agents&#10;

Accepted Answer

Chemotherapy agents are classified into several categories, including alkylating agents and antibiotics. Other categories include antimetabolites, mitotic inhibitors, tumor antagonists, and hormones. Antihormones and acidifying agents are not typically included as classifications of chemotherapy agents.

Question 7

The nurse would question an order for cyclophosphamide (Cytoxan)for a client with which of the following conditions?&#10;A) Chronic leukemia&#10;B) Carcinoma of the breast&#10;C) Multiple myeloma&#10;D) Herpes zoster infection&#10;

Accepted Answer

Cyclophosphamide is a chemotherapy medication that is used to treat certain types of cancer, including breast cancer and chronic leukemia. However, it is not used to treat herpes zoster infection, which is caused by the varicella-zoster virus. Therefore, if the nurse received an order for cyclophosphamide for a client with herpes zoster infection, she would question the order and likely consult with the healthcare provider to determine the appropriate treatment.

Question 8

After reviewing a client's laboratory test results,the nurse would conclude that which of the following would necessitate the discontinuation of fluorouracil? A) A white blood cell count of 8000/mm³ B) A thrombocyte count of 8000/mm³ C) A platelet count of 450,000/mm³ D) A hemoglobin level of 14 g/dL

Accepted Answer

A thrombocyte count of 8000/mm³ (also known as a platelet count of 8,000/mm3) is dangerously low and indicates a high risk for bleeding. Fluorouracil is an anti-cancer medication that can cause bone marrow suppression, including decreased production of platelets. Therefore, a platelet count this low would necessitate the discontinuation of fluorouracil to prevent further harm to the patient. A white blood cell count of 8000/mm³ (or 8,000/mm3) is within the normal range and would not necessitate discontinuation of fluorouracil. A platelet count of 450,000/mm³ (or 450,000/mm3) is also within the normal range. A hemoglobin level of 14 g/dL is within the normal range for an adult male and would not necessitate discontinuation of fluorouracil.

Question 9

The nurse who is assessing a client receiving cisplatin (Platinol)would not be concerned about the development of which of the following adverse effects from this chemotherapeutic agent?&#10;A) Nephrotoxicity&#10;B) Neurotoxicity&#10;C) Ototoxicity&#10;D) Pulmonary toxicity&#10;

Accepted Answer

Pulmonary toxicity is not a known adverse effect of cisplatin. However, nephrotoxicity, neurotoxicity, and ototoxicity are all potential adverse effects of cisplatin.

Question 10

The nurse overhears a client who has cancer tell the family that the physician will order an antitumor antibiotic.The nurse suspects that which of the following agents may be used?&#10;A) Thiotepa (Thioplex)&#10;B) Gemcitabine (Gemzar)&#10;C) Mitomycin (Mutamycin)&#10;D) Paclitaxel (Onxol,Taxol)&#10;

Accepted Answer

Mitomycin is an antitumor antibiotic commonly used in the treatment of various types of cancer, including breast, stomach, and pancreatic cancer. Thiotepa is an alkylating agent, Gemcitabine is a nucleoside analogue, and Paclitaxel is a taxane. While all of these agents may be used in the treatment of cancer, they are not classified as antitumor antibiotics.

Question 11

The nurse explains to a client receiving chemotherapy that leucovorin (Wellcovorin)is used in conjunction with methotrexate to do which of the following?&#10;A) Treat hyperkeratosis&#10;B) Diminish the risk of bony metastasis&#10;C) Act to increase the cancer cell kill&#10;D) Protect normal cells from toxic effects of the drug&#10;

Accepted Answer

The answer of The nurse explains to a client receiving...

Question 12

The nurse who reads a physician progress note for a client with cancer would expect which of the following drugs to be used if the plan is to use an alkylating agent?&#10;A) Busulfan (Myleran)&#10;B) Mercaptopurine (Purinethol)&#10;C) Bleomycin (Blenoxane)&#10;D) Docetaxel (Taxotere)&#10;

Accepted Answer

The answer of The nurse who reads a physician progress...

Question 13

The nurse plans to assess the client receiving dacarbazine (DTIC-Dome)for which of the following adverse drug effects?&#10;A) Nausea and vomiting&#10;B) Stomatitis&#10;C) Hemorrhagic cystitis&#10;D) Chest pain&#10;

Accepted Answer

The answer of The nurse plans to assess the client...

Question 14

What instructions should the nurse give to the client who is receiving fluorouracil therapy?&#10;A) Take the medication orally&#10;B) Get routine immunizations to prevent influenza and pneumonia&#10;C) Refrain from being immunized with live virus vaccines&#10;D) Immunize only family members&#10;

Accepted Answer

The answer of What instructions should the nurse give to...

Question 15

The nurse expects that a client will be receiving which of the following drugs after hearing that a client with cancer will be treated with a mitotic inhibitor?&#10;A) Mechlorethamine (Mustargen)&#10;B) Fluorouracil (Adrucil)&#10;C) Epirubicin (Ellence)&#10;D) Vincristine (Oncovin)&#10;

Accepted Answer

The answer of The nurse expects that a client will...

Question 16

If extravasation of intravenous fluorouracil occurs,the most appropriate nursing intervention would be to stop the infusion and&#10;A) apply warm compresses.&#10;B) give 25% hydrocortisone intramuscularly.&#10;C) apply cold compresses.&#10;D) give 20% lidocaine intravenously.&#10;

Accepted Answer

The answer of If extravasation of intravenous fluorouracil occurs,the most...

Question 17

After noting a chemotherapy order for the drug lomustine (CeeNU)in a client with cancer,the nurse concludes that which of the following is most likely the affected site?&#10;A) Breast&#10;B) Ovary&#10;C) Brain&#10;D) Stomach&#10;

Accepted Answer

The answer of After noting a chemotherapy order for the...

Question 18

Fluorouracil is ordered as an adjunct therapy to surgery.The nurse recalls that this drug is classified as which of the following types of chemotherapy drugs?&#10;A) Antimetabolite agent&#10;B) Antibiotic antitumor agent&#10;C) Alkylating agent&#10;D) Hormonal antitumor agent&#10;

Accepted Answer

The answer of Fluorouracil is ordered as an adjunct therapy...

Question 19

The client with cancer asks the nurse about the newly ordered drug tamoxifen (Nolvadex).The nurse explains that this drug is which of the following types of drugs?&#10;A) Synthetic steroidal chemotherapeutic agent&#10;B) Antitestosterone agent&#10;C) Antiestrogen agent&#10;D) Vinca alkaloid&#10;

Accepted Answer

The answer of The client with cancer asks the nurse...

Question 20

The nurse understands that a client with which of the following conditions could not be treated effectively with cyclophosphamide (Cytoxan)?&#10;A) Acute leukemia&#10;B) Drug-resistant nephrotic syndrome&#10;C) Polycythemia vera&#10;D) Mycosis fungoides&#10;

Accepted Answer

The answer of The nurse understands that a client with...

Question 21

The nurse notes that a client has an order for chemotherapy with flutamide (Eulexin)and also has an order for leuprolide (Lupron).The nurse suspects that the client has which type of metastatic cancer?

A) Testicular
B) Prostate
C) Brain
D) Bone

Accepted Answer

The answer of The nurse notes that a client has...

Question 22

The nurse places highest priority on assessing for which dose-limiting adverse effect that is associated with vinblastine (Velban)?&#10;A) Stomatitis&#10;B) Neurotoxicity&#10;C) Hyperuricemia&#10;D) Muscle pain&#10;

Accepted Answer

The answer of The nurse places highest priority on assessing...

Question 23

The nurse would assess the client receiving doxorubicin (Adriamycin)for which of the following signs of toxicity?&#10;A) Ringing in the ears&#10;B) Heart failure&#10;C) Dyspnea&#10;D) Paresthesias&#10;

Accepted Answer

The answer of The nurse would assess the client receiving...

Question 24

A client receiving chemotherapy has a new drug order for filgrastim (Neupogen).The nurse prepares to administer this drug by which of the following routes?&#10;A) Oral&#10;B) Subcutaneous&#10;C) Intramuscular&#10;D) Intravenous&#10;

Accepted Answer

The answer of A client receiving chemotherapy has a new...

Question 25

The nurse would most carefully assess a client who received fludarabine (Fludara)for evidence of myelosuppression at which of the following timeframes after infusion?&#10;A) 1 to 3 days&#10;B) 5 to 7 days&#10;C) 10 to 14 days&#10;D) 21 to 28 days&#10;

Accepted Answer

The answer of The nurse would most carefully assess a...

Question 26

The nurse suspects that the client has cancer in which of the following sites after reading an order for paclitaxel (Taxol)?&#10;A) Breast&#10;B) Colon&#10;C) Pancreas&#10;D) Bone&#10;

Accepted Answer

The answer of The nurse suspects that the client has...

Question 27

A client with cancer has an order for chemotherapy with asparaginase (Elspar).The nurse suspects that the client has which of the following types of cancer?&#10;A) Neuroblastoma&#10;B) Cancer of the colon&#10;C) Acute lymphocytic leukemia&#10;D) Prostate cancer&#10;

Accepted Answer

The answer of A client with cancer has an order...

Question 28

A client with cancer is receiving interferon $\alpha$ 2a (Roferon-A).The nurse teaches the client that occurrence of which of the following is a priority reason to notify the physician?&#10;A) Dizziness&#10;B) Fatigue&#10;C) Edema&#10;D) Suicidal ideation&#10;

Accepted Answer

The answer of A client with cancer is receiving interferon...

Question 29

A client who has a history of depression is receiving chemotherapy for cancer with altretamine (Hexalen).The nurse checks the medication administration record to ensure that the client does not have which of the following types of drugs ordered,which would be contraindicated with altretamine?

A) First-generation antidepressant
B) Tricyclic antidepressant
C) Selective serotonin reuptake inhibitor
D) Monoamine oxidase inhibitor

Accepted Answer

The answer of A client who has a history of...

Question 30

The nurse administering chemotherapy to a client would be especially careful to observe the client for an allergic reaction during the first hour of the infusion if the client were receiving which of the following chemotherapy drugs?

A) Cyclophosphamide (Cytoxan)
B) Doxorubicin (Adriamycin)
C) Paclitaxel (Taxol)
D) Busulfan (Myleran)

Accepted Answer

The answer of The nurse administering chemotherapy to a client...

Deck 56: Antineoplastic Chemotherapy Agents