Question 1

Androgen treatment can be used to increase hematopoiesis. This is due to:&#10;A) Increased growth hormone production&#10;B) Increased erythropoietin receptor sensitivity in bone marrow&#10;C) GnRH receptor up regulation&#10;D) Increased renal erythropoietin production&#10;E) Increased muscle mass effect

Accepted Answer

Androgens have been shown to stimulate erythropoiesis by increasing renal erythropoietin production. Androgens also have a direct effect on erythrocyte maturation.

Question 2

Benign prostatic hypertrophy is treated with finasteride. Finasteride acts to:&#10;A) Block the conversion of testosterone to 5-alpha-dihydrotestosterone&#10;B) Antagonize alpha-1 adrenergic receptors&#10;C) Up regulate 5-alpha-reductase type II&#10;D) Treat prostate cancer&#10;E) Decrease free testosterone and estrogen levels

Accepted Answer

Finasteride (Proscar) is a competitive inhibitor of 5α-reductase type II that blocks conversion of testosterone to 5α-DHT, reducing prostate size. This results in increased free testosterone, which is then converted to estrogen. This can result in unwanted side effects such as gynecomastia.

Deck 41: Androgens and Antiandrogens