Deck 26: Antithrombotic Drugs

Question 1

Heparin differs from low molecular weight heparins (LMWH) in that:

A) LMWHs can be given PO
B) LMWHs' effectiveness is measured by PT and INR
C) LMWHs have a greater capacity to directly inhibit factor Xa
D) LMWHs cannot be reversed by protamine sulfate
E) B and C

Answer 1

LMWHs have a greater capacity to directly inhibit factor Xa

Question 2

Two vitamin K-dependent factors made in the liver are proteins C and S.

A) These are part of the thrombus-forming cascade.
B) These act primarily to regulate sodium excretion.
C) These proteins function to inactivate clotting factors V and VIII.
D) These proteins are clinically used to treat myocardial infarction and stroke.
E) These proteins are not affected by warfarin.

Answer 2

These proteins function to inactivate clotting factors V and VIII.

Question 3

Warfarin administration:

A) Is used to lyse deep vein thromboses
B) Interferes with the production of clotting factor VII
C) Can be reversed with the use of vitamin K
D) Is monitored with PTT levels
E) Is ideal when rapid-acting, short-duration treatment is indicated

Answer 3

Can be reversed with the use of vitamin K