Deck 29: Chemotherapy for the Control of Periodontal Diseases

Question 1

All of the following statements are true regarding controlled-release drug delivery systems except which one?

A) Indicated in sites with increased clinical attachment loss and deep pockets
B) Require professional placement into disease site
C) Provide sustained drug delivery over long periods of time
D) Provide relatively high doses of systemic drug concentrations

Answer 1

Provide relatively high doses of systemic drug concentrations

Question 2

The American Dental Association (ADA)Seal of Acceptance Program has three classifications regarding products that it reviews.All of the following are classifications except which one?

A) Accepted
B) Provisionally accepted
C) Approved
D) Unacceptable

Answer 2

Approved

Question 3

What is the most effective antiplaque and antigingivitis over-the-counter (OTC)agent that has received the American Dental Association (ADA)seal for therapeutic efficacy?

A) Atridox
B) Peridex
C) Listerine
D) Cepacol

Answer 3

Listerine

Question 4

Dental caries and inflammatory periodontal diseases are complex infectious disease states that require the colonization of specific bacterial pathogens;therefore control of oral biofilm is an essential component of any long-term strategy to prevent and control these dental diseases.

A) Both statements are true.
B) Both statements are false.
C) The first statement is true;the second statement is false.
D) The first statement is false;the second statement is true.

Question 5

Which of the following terms describes the ability of an active therapeutic agent to be retained in the oral cavity and to continue to be released over an extended period of time without losing its potency?

A) Antimicrobial
B) Bactericidal
C) Substantivity
D) Bacteriostatic

Question 6

All of the following are research guidelines provided by the American Dental Association Council on Scientific Affairs except which one?

A) Study population should be representative of typical users.
B) Studies should be at least 2 months long.
C) Study product should be used in its normal regimen.
D) At least two studies should be conducted by independent researchers.

Question 7

Which of the following oral chemotherapeutic agents is the most common delivery system for self-applied local application?

A) Water
B) Fluoride
C) Mouthwash
D) Dentifrice

Question 8

A subantimicrobial systemic dose of antibiotics refers most closely to which of the following statements?

A) Antibacterial with shifts in normal periodontal flora
B) Used for relatively short periods of time
C) Administration of a reduced quantity of drug for alternative purposes
D) Used in clients normally sensitive to antibiotics

Question 9

Which of the following is the term used to describe the blunt-ended,needlelike tip used for professional irrigation of periodontal pockets?

A) Jet tip
B) Cannula
C) Irrigant
D) None of the above

Question 10

In controlled drug delivery for treatment of chronic periodontitis,a contraindication to the use of minocycline microspheres is a client's known sensitivity to steroids.Also,the minocycline product needs to be removed after it has been in place for about 10 days.

A) Both statements are true.
B) Both statements are false.
C) The first statement is true,and the second statement is false.
D) The first statement is false,and the second statement is true.

Question 11

All of the following statements are true regarding the systemic delivery of antibiotics except which one?

A) Antibiotics are ingested and then delivered via the bloodstream.
B) Antibiotics access the subgingival microflora via gingival crevicular fluid.
C) This delivery method has demonstrated efficacy on periodontal parameters.
D) This method delivers high concentrations to periodontitis sites compared with locally delivered methods.

Question 12

All of the following statements are true regarding the current understanding surrounding the carcinogenicity of oral rinses incorporating alcohol except which one?

A) The association between the alcohol in oral rinse and oral cancer has been substantiated.
B) Alcohol is included in oral rinse to emulsify the antimicrobial ingredients.
C) Ethanol is the type of alcohol used in oral rinses.
D) Other products in alcoholic beverages rather than the alcohol are carcinogenic.

Question 13

Chlorhexidine gluconate is the most widely investigated broad-spectrum antimicrobial agent used in oral chemotherapeutics.It is typically used in prescription oral rinses and for professional irrigation or periodontal pockets.

A) Both statements are true.
B) Both statements are false.
C) The first statement is true,and the second statement is false.
D) The first statement is false,and the second statement is true.

Question 14

All of the following are true regarding the active ingredient within an oral chemotherapeutic agent except which one?

A) Responsible for reducing or altering the microbial pathogens
B) Equally effective across various delivery systems
C) Categorized by how the agent disables the microorganism
D) Oral antiseptics have received the most research attention

Question 15

Which of the following agencies in North America exists to help reduce the risk of harm to clients and diminish their confusion surrounding misbranding of oral chemotherapeutics?

A) The American Dental Association Council on Scientific Affairs
B) The Canadian Dental Association
C) The U.S.Food and Drug Administration
D) All of the above

Question 16

The two dimensions of oral chemotherapeutics are the active ingredient and mode of delivery.The delivery system can be either locally or systemically applied.

A) Both statements are true.
B) Both statements are false.
C) The first statement is true;the second statement is false.
D) The first statement is false;the second statement is true.

Question 17

The literature surrounding the therapeutic efficacy of professional subgingival irrigation is equivocal because adequate concentrations of the active ingredient are unable to be maintained for sufficient periods of time.

A) Both the statement and the reason are true,and they are related.
B) Both the statement and the reason are true,but they are unrelated.
C) The statement is true,but the reason is false.
D) The statement is false,but the reason is true.
E) Both the statement and the reason are false.

Question 18

Oral chemotherapeutics are used to control plaque and prevent dental and periodontal diseases.Which of the following is least true regarding the typical use of oral chemotherapeutics?

A) Replace traditional mechanical oral biofilm control measures
B) Describe the incorporation of an active ingredient within a delivery system
C) Capable of reducing the overall quantity of bacterial pathogens
D) Able to alter pathogenic microorganisms,reducing pathogenicity

Question 19

Which one of the following is true regarding the chlorhexidine gluconate chip?

A) Must be professionally removed
B) Marketed under the trade name Atridox
C) Suppresses bacteria for over 2 months
D) Contraindicated for clients allergic to the tetracycline family of antibiotics

Question 20

Which of the following products is not an antibiotic-based controlled-release drug?

A) Actisite
B) PerioWave
C) Elyzol
D) Arestin

Question 21

Although many active ingredients are present in over-the-counter oral rinses and dentifrices,very few have received the ADA Seal of Acceptance because of which of the following reasons?

A) The product has demonstrated reductions in plaque and gingivitis in short-term studies.
B) The product has been demonstrated efficacious only in in vitro studies.
C) The product has shown plaque reductions but not gingivitis reductions.
D) All of the above are correct.

Question 22

Which of the following is a negative side effect common to chlorhexidine gluconate-based oral rinses and makes its long-term use inadvisable in most individuals?

A) Xerostomia
B) Fluorosis
C) Soft-tissue ulcerations
D) Extrinsic tooth staining

Question 23

Which of the following is not a condition associated with systemic antibiotic therapy?

A) Increase in photosensitivity
B) Decreased effectiveness of oral contraceptives
C) Depressed prothrombin activity
D) All of the above are conditions associated with systemic antibiotic therapy.

Question 24

All of the following are ideal properties of a home oral rinse except which one?

A) Broad-spectrum activity
B) Palatable for the user
C) Insoluble
D) Safe to use over long periods of time

Question 25

Which one of the following is true regarding oxygenating agents?

A) Have had an increase in the oxidation number
B) Marketed commercially as Amosan and Glyoxide
C) Demonstrated therapeutic efficacy in plaque and gingivitis reductions
D) Received the American Dental Association (ADA)Seal of Acceptance