Deck 14: Immunology of Transplantation

Question 1

To collect hematopoietic stems cells,
a.inject granulocyte colony stimulating factor into the patient and collect stem cells by leukapheresis
b.the cells that are collected are further isolated using anti-CD34 and CD133
c.A and B
d.none of the above

Answer 1

A and B

Question 2

Symptoms of graft-versus-host disease can include
a.diarrhea
b.rashes
c.pneumonitis
d.A and B
e.all of the above

Answer 2

all of the above

Question 3

In graft-versus-host disease,
a.a kidney transplant releases toxic products that affect the host
b.a liver transplant releases toxic products that affect the host
c.the bone marrow transplant attacks the recipient as being foreign
d.the recipient sends cells and molecules to attack the bone marrow

Answer 3

the bone marrow transplant attacks the recipient as being foreign

Question 4

An allograft is a graft from
a.an individual of the same species
b.an identical twin
c.one part of a patient's body to another part
d.a different species

Question 5

ABO blood group antigens are found on
a.red blood cells
b.lymphocytes
c.endothelial cells
d.A and B
e.all of the above

Question 6

Cyclosporin A blocks
a.B-cell reaction with a transplant
b.antibody reaction with a transplant
c.T-cell receptor signaling IL-2 production
d.antigen-presenting cells

Question 7

To determine class II molecule compatibility of a transplant,
a.mixed lymphocyte reactions were once performed, but now genotyping is performed
b.mixed lymphocyte reactions were once performed, but now flow cytometry is performed
c.microcytotoxicity was once performed, but now the primary test is flow cytometry
d.none of the above

Question 8

An autograft is a graft from
a.an individual of the same species
b.an identical twin
c.one part of a patient's body to another part
d.a different species

Question 9

A xenograft is a graft from
a.an individual of the same species
b.an identical twin
c.one part of a patient's body to another part
d.a different species

Question 10

In addition to compatibility at ABO and HLA antigens,
a.patients should be screened for minor histocompatibility antigens
b.patients should be tested for CMV
c.A and B
d.patients should meet each other to be sure there is not additional conflict

Question 11

A first set rejection is
a.an antibody-mediated graft rejection
b.the rejection of the allograft at first encounter
c.the rejection of the allograft after a second encounter
d.the rejection that is due to ABO antigens

Question 12

The universal donor
a.A+ Rh+
b.B+ Rh+
c.O Rh+
d.O Rh-

Question 13

Acute rejection can be decreased by
a.plasmapheresis
b.immunosuppressive drugs such as Rituxan
c.a better match
d.A and C
e.B and C

Question 14

Beads used in the multiplex system are
a.coated with HLA antigens and incubated with the patient's serum to determine whether the patient has antibodies to different HLA types
b.coated with the patient serum and incubated with the donor's lymphocytes to determine whether the patient has antibody to the donor's HLA type
c.coated with HLA antigens and incubated with the donor's serum to determine whether the donor has antibodies to different HLA types
d.coated with the donor's serum and incubated with the recipient's lymphocytes to determine whether the donor has antibody to the recipient's HLA type

Question 15

An isograft is a graft from
a.an individual of the same species
b.an identical twin
c.one part of a patient's body to another part
d.a different species

Question 16

A cross match done at 37º C will detect which of the following against the donor cells?
a.all antibodies
b.IgG
c.IgM
d.IgA

Question 17

Chronic rejection
a.can be prevented by immunosuppressant drugs
b.involves T cells only
c.involves humoral and cell-mediated responses and other mechanisms
d.plays only a minor role in the overall acceptance or rejection of a transplanted organ

Question 18

Detection of antibodies present in the recipient that will react with donor antigens
a.is not necessary because immunosuppression can take care of this
b.is performed using a luminex multiplex procedure
c.is performed using a mixed lymphocyte reaction
d.is performed using antibodies from women who have been pregnant multiple times

Question 19

Acute graft rejection is mediated by
a.antibodies
b.neutrophils
c.T cells
d.A and B
e.A and C

Question 20

Hyperacute rejection on the operating table is due to
a.T cells that react with class I molecules on the donated organ
b.T cells that react to class II molecules on the donated organ
c.donor T cells that react to the recipient lymphocytes
d.antibody in the recipient that reacts to donor antigens

Question 21

A microcytotoxicity test performed in transplantation involves
a.antibody to ABO antigens + complement-killing endothelial cells
b.white blood cells from the donor mixed with antibodies to HLA antigens and complement
c.white blood cells from the recipient mixed with antibodies to HLA antigens and complement
d.B and C
e.A and B

Question 22

Markers for stem cells include
a.CD34
b.CD 44
c.CD 133
d.A and B
e.A and C

Question 23

Which of the following cells mediate(s) transplantation rejection?
a.CD4+
b.CD8+
c.macrophage
d.A and B

Question 24

Viruses for which donors should be screened are
a.hepatitis B, hepatitis C, HIV
b.hepatitis B, hepatitis C, HIV, West Nile virus
c.hepatitis B, hepatitis C, HIV, West Nile virus, human T-lymphotropic virus (HTLV)
d.hepatitis B, hepatitis C, HIV, West Nile virus, rubella