Deck 18: Genetic Considerations in Pharmacology

Question 1

Cost-effectiveness is a potential barrier to genetic-based therapies.

Answer 1

True

Question 2

Determining the kind or dosage of drug therapy on the basis of an individual's genetic status:

A) is an example of genetic polymorphism.
B) may increase the cost of health insurance for the whole community.
C) is called drug striation.
D) may decrease the incidence of serious drug adverse reactions for some clients.

Answer 2

may decrease the incidence of serious drug adverse reactions for some clients.

Question 3

The types of gene therapy include:

A) somatic and germline.
B) psychosomatic and germline.
C) somatic and viraline.
D) psychosomatic and viraline.

Answer 3

somatic and germline.

Question 4

One trial that clearly illustrated problems with gene therapy was among children with severe combined immunodeficiency. What was the serious secondary effect believed to be a result of this form of therapy?

A) Progression to HIV
B) Increased mortality from the initial diagnoses
C) Leukaemia
D) Heart failure

Question 5

Which of the following are ethical issues associated with pharmacogenetics? Select all that apply.

A) Keeping data secure
B) Insurance risk
C) Cost of therapy
D) Lack of data on effectiveness of treatment

Question 6

In a pharmacogenetic context,the potential negative clinical consequences of being classified as a responder is:

A) ineffectiveness of the drug treatment.
B) less frequent drug dosing.
C) drug toxicity.
D) that the drug has a narrower therapeutic index.

Question 7

Two techniques used in gene therapy include in vitro and vector methods.

Question 8

A client that you are caring for has advanced kidney disease and is about to commence drug therapy.In order to maintain safe plasma drug levels,the prescriber might have to consider:

A) increasing the dosage.
B) decreasing the dosage.
C) increasing the frequency of dosing.
D) increasing the dose and frequency of administration.

Question 9

Which one of the following factors is likely to result in higher plasma drug levels?

A) Taking a water-soluble drug during a meal
B) Administering a drug orally when a client is experiencing an episode of severe diarrhoea
C) Administering the narcotic analgesic morphine to a person with cirrhosis of the liver
D) Administering a drug that is subject to significant metabolism to a person whose occupation involves handling chemicals that induce microsomal enzymes.

Question 10

If a person who has an inherited disorder wished to minimise the odds of passing that genetic materials to their offspring,germline therapy will be of no use.

Question 11

How many human enzymes have been associated with drug metabolism and polymorphisms?

A) Less than 20
B) More than 20
C) A minimum of 50
D) None

Question 12

Somatic gene therapy uses what form of cells?

A) Sperm cells
B) Psychosomatic cells
C) Somatic cells
D) Ovarian cells