Deck 7: Endocrine Agents

Question 1

Which of the following statements about tamoxifen is FALSE?

A) Hot flashes are a common adverse reaction.
B) Tamoxifen has no drug interactions.
C) Tamoxifen helps decrease bone loss in postmenopausal women.
D) Tamoxifen is used for the treatment and prevention of breast cancer.

Answer 1

B

Question 2

Which of the following is a common adverse reaction of Fosamax?

A) Abdominal pain
B) Esophageal ulcers
C) Bone pain
D) Hypercalcemia

Answer 2

A

Question 3

Which of the following is an appropriate dose of risedronate for the treatment of osteoporosis in females?

A) 5 mg daily
B) 70 mg weekly
C) 35 mg weekly
D) A and C

Answer 3

D

Question 4

All of the following are adverse reactions of calcitonin, EXCEPT:

A) Nasal irritation
B) Esophagitis
C) Rhinitis
D) Epistaxis

Question 5

All of the following are indications for the use of Estradiol, EXCEPT:

A) Treatment of vasomotor symptoms
B) Prevention of osteoporosis
C) Treatment of osteoporosis
D) Treatment of abnormal uterine bleeding

Question 6

Which of the following is/are contraindications for the use of estrogen-containing products?

A) Active thromboembolic disorders
B) History of diabetes
C) Severe liver disease
D) A and C

Question 7

Which of the following medications interact with Vivelle?

A) Rifampin
B) Phenytoin
C) Carbamazepine
D) All of the above

Question 8

What do Miacalcin and Fosamax have in common?

A) They are both used for the treatment of osteoporosis.
B) Abdominal pain is the most common adverse reaction of both medications.
C) They both have an oral formulation.
D) Antacids may decrease the absorption of both medications.

Question 9

Ibandronate is used for which of the following indications?

A) Treatment of osteoporosis
B) Hypercalcemia of malignancy
C) Metastatic bone disease
D) All of the above

Question 10

All of the following medications contain estrogen, EXCEPT:

A) Climara
B) Premarin
C) Depo-Provera
D) Estraderm

Question 11

All of the following are common adverse reactions of estrogen-containing products, EXCEPT:

A) Vaginal bleeding
B) Breast tenderness
C) Nausea
D) Vasomotor symptoms

Question 12

Which of the following is an example of a biphasic combined oral contraceptive?

A) Desogen
B) Lo-Ovral
C) Mircette
D) Ortho-Novum 7/7/7

Question 13

Which of the following is the appropriate dose of Evista for the treatment of osteoporosis?

A) 30 mg twice daily
B) 60 mg daily
C) 90 mg daily
D) 120 mg twice daily

Question 14

Which of the following is/are common adverse reactions of high-dose glucocorticosteroids?

A) Gastrointestinal irritation
B) Weight gain
C) Glucose intolerance
D) All of the above

Question 15

Which of the following is a side effect of rapid withdrawal of high-dose glucocorticosteroids?

A) Hyperglycemia
B) Adrenal insufficiency
C) Thrombocytopenia
D) Weight gain

Question 16

All of the following are important counseling points about the use of transdermal systems containing estrogen, EXCEPT:

A) The transdermal system should be applied to the breasts and thigh.
B) Only one transdermal system should be worn at any one time.
C) Using a sauna may decrease the adhesion of the system.
D) Climara is a continuous transdermal system for once weekly administration.

Question 17

What is the appropriate dose of Depo-Provera for the prevention of pregnancy?

A) 5-10 mg daily
B) 150 mg IM every 3 months
C) 150 mg IM every 6 months
D) 104 mg SQ every month

Question 18

Which of the following is/are a combination of conjugated estrogen and progesterone formulation?

A) Prempro
B) Premarin
C) Premphase
D) A and C

Question 19

All of the following medications affect the levels of combined oral contraceptives, EXCEPT:

A) Antibiotics
B) Barbiturates
C) Levetiracetam
D) Protease inhibitors

Question 20

All of the following are common adverse reactions of Synthroid, EXCEPT:

A) Fatigue
B) Weight gain
C) Heat intolerance
D) Increased appetite

Question 21

Which of the following is an estrogen-only containing medication?

A) Provera
B) Climara
C) Prempro
D) A and B

Question 22

All of the following are important counseling points about Depo-Provera, EXCEPT:

A) The menstrual cycle may be disrupted at the beginning of treatment.
B) The IM formulation should be given every 3 months.
C) Long-term use can cause bone loss.
D) Progestin withdrawal bleeding usually occurs 3-6 months after discontinuing treatment.

Question 23

Which of the following is a contraindication for the use of Ortho Try-Cyclen?

A) History of peptic ulcer disease
B) Use of antibiotics
C) Severe liver disease
D) History of diabetes

Question 24

What is a normal starting dose of levothyroxine?

A) 50 mcg daily
B) 125 mcg daily
C) 25 mg daily
D) 100 mg daily

Question 25

Which of the following agents is a triphasic combined oral contraceptive?

A) Seasonale
B) Ortho Nova 7/7/7
C) Ortho Cyclin
D) Mircette

Question 26

Which of the following statements is/are true about Boniva?

A) Only bisphosphonate indicated in patients on hemodialysis
B) Used in the treatment of hypocalcemia
C) Can be given once a month
D) All of the above

Question 27

What is the usual dose of Miacalcin for the treatment of osteoporosis?

A) One tablet daily
B) One spray in each nostril twice a day
C) One spray in one nostril daily
D) One spray in one nostril twice a day

Question 28

Which of the following is the appropriate dose of Fosamax for the treatment of osteoporosis?

A) 5 mg daily
B) 10 mg weekly
C) 35 mg weekly
D) 70 mg weekly

Question 29

All of the following statements about Actonel are true, EXCEPT:

A) Abdominal pain is a common adverse effect.
B) Patients should not lie down for 30 minutes after taking the medication.
C) Vitamin D can decrease its absorption.
D) Not recommended in patients with creatinine clearance less than 30 ml/min.

Question 30

Which of the following medications should not be taken with bisphosphonates?

A) Tums
B) Penicillin
C) NSAIDs
D) A and C

Question 31

Which of the following are appropriate counseling points for someone taking the progestin only pill?

A) Take at the same time every day.
B) If the medication is taken more than 3 hours late a different contraceptive method is needed for at least 48 hours.
C) One of the brand names is Micronor.
D) All of the above.

Question 32

Which of the following medications have been associated with rare cases of osteonecrosis of the jaw?

A) Thyroid replacement therapy
B) High-dose steroids
C) Bisphosphonates
D) Progestin-only contraceptives

Question 33

Which of the following is the most potent anti-inflammatory glucocorticoid?

A) Dexamethasone
B) Prednisone
C) Methylprednisolone
D) Cortisone

Question 34

All of the following statements about raloxifene are true, EXCEPT:

A) It is contraindicated in pregnancy.
B) It is a selective estrogen receptor modulator.
C) Its brand name is Nolvadex
D) The usual dose is 60 mg daily.

Question 35

All of the following are monophasic combined oral contraceptives, EXCEPT:

A) Yaz
B) Desogen
C) Loestrin 24 FE
D) Trivora