Deck 4: Antineoplastics

Question 1

Which of the following is an important counseling point for patients taking Xeloda?

A) Report any fever or sign of infection to your physician.
B) Stop using if nausea occurs.
C) Take orally once a day.
D) Take on empty stomach.

Answer 1

A

Question 2

What medication can be used to reduce hemorrhagic cystitis from the use of high-dose cyclophosphamide?

A) Mannitol
B) Mesna
C) Leucovorin
D) Dexrazoxane

Answer 2

B

Question 3

Which of the following is a possible long-term complication associated with the use of doxorubicin?

A) Mucositis
B) Heart failure
C) Emesis
D) Peripheral neuropathy

Answer 3

B

Question 4

Which of the following is a vesicant that causes tissue necrosis if extravasation occurs, and should be administered through a central intravenous (IV) line?

A) Capecitabine
B) Methotrexate
C) Cytarabine
D) Doxorubicin

Question 5

Which of the following chemotherapy agents is considered highly emetogenic?

A) Cisplatin
B) Paclitaxel
C) Gemcitabine
D) 5-Fluorouracil

Question 6

A patient with a deficiency in dihydropyrimidine dehydrogenase (DPD) can experience increased toxicities from which of the following agents?

A) Gemcitabine
B) 5-fluorouracil
C) Cytarabine
D) Imatinib

Question 7

Imatinib is a tyrosine kinase inhibitor used to treat all of the following, EXCEPT:

A) Lung cancer
B) Chronic myelogenous leukemia
C) Gastrointestinal stromal cell tumors
D) Ph+ acute lymphoblastic leukemia

Question 8

Which of the following is a correct dose for intrathecal methotrexate in an adult?

A) 1 mg/m2
B) 40 mg/m2
C) 1 mg
D) 15 mg

Question 9

All of the following are associated with infusion reactions, EXCEPT:

A) Rituximab
B) Trastuzumab
C) Paclitaxel
D) Methotrexate

Question 10

Cyclophosphamide is FDA-approved for all of the following indications, EXCEPT:

A) Non-Hodgkin's lymphoma
B) Breast cancer
C) Chronic lymphocytic leukemia
D) Rheumatoid arthritis

Question 11

All of the following supportive care may be needed with high-dose cytarabine therapy for treating acute myelogenous leukemia, EXCEPT:

A) Antiemetics
B) Steroid eye drops
C) Intravenous fluids
D) Potassium chloride

Question 12

All of the following agents should be dose-reduced for renal impairment, EXCEPT:

A) Paclitaxel
B) Cisplatin
C) Capecitabine
D) Methotrexate

Question 13

A painful rash that occurs on the palms of the hands and feet called Palmar-Plantar Erythrodysesthesia is commonly caused by which of the following agents?

A) Cisplatin
B) Rituximab
C) Capecitabine
D) Imatinib

Question 14

Which of the following agents cannot be administered orally?

A) Capecitabine
B) Cyclosphosphamide
C) Imatinib
D) Gemcitabine

Question 15

All of the following have dosing recommendations for pediatric patients, EXCEPT:

A) Doxorubicin
B) Docetaxel
C) Methotrexate
D) Mercaptopurine

Question 16

Thiopurine methyltransferase (TPMT) genotyping may identify individuals at high risk for toxicity for which of the following agents?

A) Mercaptopurine
B) Methotrexate
C) Cytarabine
D) Trastuzumab

Question 17

A patient with third spacing such as ascites should not receive which one of the following agents?

A) Paclitaxel
B) Carboplatin
C) Cyclophosphamide
D) Methotrexate

Question 18

The Calvert formula, which estimates the dose needed to achieve a desired AUC (area under the curve) target, is frequently used to dose which of the following agents?

A) Carboplatin
B) Cisplatin
C) Methotrexate
D) Doxorubicin

Question 19

Which of the following kills tumors by causing strand breaks in DNA resulting in cell death?

A) Capecitabine
B) Cyclophosphamide
C) Docetaxel
D) Mercaptopurine

Question 20

Which of the following causes apoptosis to tumor cells by inhibiting cell mitosis?

A) Paraplatin
B) Gemcitabine
C) Gleevec
D) Taxol

Question 21

Mercaptopurine has a significant drug interaction requiring dose modification with which of the following drugs?

A) Allopurinol
B) Corticosteroids
C) Ibuprofen
D) Leucovorin

Question 22

Use of which of the following drugs is contraindicated during therapy with rituximab?

A) Dexamethasone
B) Diphenhydramine
C) FluMist nasal vaccine
D) Attenuated influenza vaccine

Question 23

A patient receiving cytarabine should be monitored frequently during therapy for which of the following side effects?

A) Electrocardiogram for cardiotoxicity
B) Liver function tests for hepatotoxicity
C) Mental status for neurotoxicity
D) Physical exam for alopecia

Question 24

Which of the following is used to treat breast cancers that specifically overexpress the oncogene HER2/neu?

A) Gemcitabine
B) Imatinib
C) Docetaxel
D) Trastuzumab

Question 25

Cytarabine is commonly used to treat which of the following cancers?

A) Acute myelogenous leukemia
B) Breast cancer
C) Colon cancer
D) Lung cancer

Question 26

Which of the following chemotherapy agents should be dose-reduced for hepatic dysfunction?

A) Carboplatin
B) Paclitaxel
C) Rituximab
D) Trastuzumab

Question 27

Imatinib (Gleevec) could potentially interact with all of the following, EXCEPT:

A) Acetaminophen
B) Carbamazepine
C) Lansoprazole
D) Fluconazole

Question 28

Which of the following antineoplastic agents is also commonly used for rheumatoid arthritis?

A) Capecitabine
B) Cytoxan
C) Purinethol
D) Methotrexate

Question 29

Which of the following antineoplastic agents is also used topically to treat basal cell skin cancers?

A) Cytarabine
B) Doxorubicin
C) Fluorouracil
D) Methotrexate

Question 30

Recommendations to consider antiviral prophylaxis for herpes simplex infections exist for patients receiving which of the following agents?

A) Temozolomide
B) Bortezomib
C) Cetuximab
D) Vincristine

Question 31

What key counseling points should be discussed with a patient starting vincristine?

A) Self-limiting diarrhea is common with this agent.
B) Report any numbness or tingling in hands or feet.
C) Thomboytopenia is common with this agent.
D) Report any rash that develops within first 2 weeks.

Question 32

Which of the following over-the-counter medications should be avoided a few days surrounding administration of pemetrexed?

A) Folic acid
B) Acetaminophen
C) Ibuprofen
D) Loratidine

Question 33

Ibrutinib has the potential to interact with which of the following agents?

A) Apixaban
B) Ranitine
C) Metformin
D) Lisinopril

Question 34

Which of the following antineoplastic agents has restricted distribution and requires prescribers, pharmacies, and patients to be enrolled in the REVLIMID REMS Program?

A) Imatinib
B) Temozolomide
C) Lenalodimide
D) Tamoxifen

Question 35

Which of the following agents is a checkpoint inhibitor that allows for antitumor immune responses via T-cell activation?

A) Cetuximab
B) Nivolumab
C) Bevacizumab
D) Trastuzumab