Deck 11: Transmucosal Drug Delivery

Question 1

The median turnover time of the buccal mucosa is shorter than that of the sublingual mucosa.

Answer 1

True

Question 2

Basement membrane,also known as basal lamina,is a non-cellular structure that separates the epithelium from the connective tissue.

Answer 2

True

Question 3

Phospholipids can be classified as a non-polar lipid.

Answer 3

False

Question 4

Polar lipids located in the intercellular spaces of the buccal/sublingual mucosa are responsible for:

A) Higher permeation of lipophilic drugs
B) Increased fluidity
C) a and b

Question 5

Overall,buccal mucosa is composed of more lipids than sublingual mucosa.

Question 6

Saliva consists of:

A) α-amylase
B) Water
C) Electrolytes
D) All of the above

Question 7

Bio-adhesive dosage systems are an effective way of delivering drugs in the oral cavity due to mucin's water holding capacity and ability to adhere to the epithelium.

Question 8

The major routes of drug transport across the oral mucosa can be classified as transcellular and paracellular.

Question 9

Transcellular drug transport is defined as passage across the intercellular spaces.

Question 10

TR146,EpiOral^TM are examples of in vitro cell culture models of buccal mucosa.

Question 11

Solid dosage forms can be classified into quick dissolving and slow dissolving based on their rate of mucosal permeation.

Question 12

Quick dissolving dosage forms typically dissolve in 5-10 minutes in the oral cavity.

Question 13

Hydrogels are composed of swellable hydrophilic polymers that swell on contact with saliva in the oral cavity.

Question 14

Drug delivery through the oral cavity includes which of the following? More than one answer may be correct.

A) Gingival delivery
B) Buccal delivery
C) Ocular delivery
D) Sublingual delivery

Question 15

Buccal mucosa has which of the following? More than one answer may be correct.

A) A thicker epithelium than sublingual mucosa
B) A shorter median turnover time than sublingual mucosa
C) Smaller surface area than sublingual mucosa
D) All of the above
E) Fewer lipids than sublingual mucosa

Question 16

Fill in the blank: One major goal of mucosal bio-adhesive drug delivery systems is to ______ the retention time in the oral cavity.

Question 17

Fill in the blank: Quick dissolving drug delivery systems release drug by ????_______ within few seconds to a minute upon contact with saliva.

Question 18

Fill in the blank: Chewable tablets,sublingual tablets,lollipops and mucoadhesive tablets are examples of ________ dissolving dosage forms.

Question 19

Fill in the blank: NovaMist^TM and RapidMist^TM are examples of ________- based buccal drug delivery systems.

Question 20

Fill in the blank: _______ are made of bioadhesive polymers that provide controlled release of drug while adhering to mucosa for long periods of time.

Question 21

Fill in the blank: ________ are thin flexible strips composed of a drug dissolved/dispersed in a water-dissolving polymer,which hydrates,adheres and quickly dissolves within few seconds when placed in the oral cavity.

Question 22

Which of the following are common characteristics of oral thin films? More than one answer may be correct.

A) Films are formulated with gum base as the primary component
B) Films are usually prepared by casting the drug formulation onto a moving web where it gets dried or cooled resulting in a thin flexible film
C) Films are thin flexible strips composed of a drug dissolved/dispersed in a water-dissolving polymer
D) Films are monolithic matrices

Question 23

Fill in the blank: An advantage of using liposomal preparations for oral mucosal delivery is that it results in ___________ penetration through the permeability barrier