Deck 12: Transdermal Drug Delivery

Question 1

Transdermal patches are generally meant for:

A) Localized delivery to the skin
B) Systemic delivery via the skin route

Answer 1

B

Question 2

The epidermis is perfused with a capillary network.

Answer 2

False

Question 3

Which layer of skin is the rate limiting barrier for transdermal delivery?

A) Dermis
B) Epidermis
C) Stratum corneum
D) Stratum germanitivum

Answer 3

C

Question 4

Charged molecules can penetrate through the skin better than uncharged molecules.

Question 5

_____________ serves as a driving force for passive diffusion of molecules through skin.

A) Time
B) Flux
C) Stratum corneum
D) Concentration gradient of drug between formulation and skin

Question 6

A drug is _________ at a pH below the pKa if it is a weak acid and _________ at a pH below the pKa if it is a weak base.

A) Unionized,ionized
B) Unionized,unionized
C) Ionized,ionized
D) Ionized,unionized

Question 7

Name three types of polymers used as pressure sensitive adhesives in transdermal patches.

Question 8

Name three types of designs for patches currently on the market.

Question 9

It is recommended that transdermal patches should NOT be applied to

A) Clean Skin
B) Dry skin
C) Hairless skin
D) Abraded skin

Question 10

A drug in adhesive type of patch typically contains a rate limiting membrane to ensure zero order release of drug.

Question 11

Which of the following is NOT true?

A) The Franz diffusion cell is a tool used to perform in vitro permeation studies
B) The receptor compartment of a franz cell is set at 32C to mimic skin surface temperature
C) The receptor compartment of a franz cell must be stirred continuously to maintain sink conditions
D) Skin membranes used for franz cells include guinea pig,rat,mouse,and human

Question 12

Which type of patch results in leakage if cut with scissors?

A) Matrix
B) Drug-in-adhesive
C) Reservoir

Question 13

Which of the following best describes proper patch usage?

A) Applying some heat,applying to the different site,reusing an old patch to prevent wastage
B) Avoiding heat,applying to the same site,discarding an old patch with adhesive side folded
C) Applying some heat,applying to the same site,discarding an old patch with adhesive side folded
D) Avoiding heat,applying to different site,discarding an old patch with adhesive side folded

Question 14

Describe the various instruments used to test patches.

Question 15

For a patient prescribed nicotine patches for smoking cessation,the nicotine dose over the treatment duration _________.

A) Stays the same
B) Is reduced gradually
C) Is increased gradually

Question 16

Which of the following is available on the U.S. market as a transdermal patch?

A) Cephalexin
B) Acetaminophen
C) Fentanyl
D) None of the above

Question 17

Name three active transdermal delivery techniques which could enable delivery of macromolecules such as peptides and proteins across skin.

Question 18

Iontophoresis works on the principle of ____________.

A) Like repels like
B) Positive repels negative
C) Drug repels excipients
D) None of the above

Question 19

Sonophoresis acts directly on the drug to enhance its permeability across skin.

Question 20

Microchannels formed by microneedles are __________ in nature.

A) Hydrophilic
B) Hydrophobic
C) Lipophilic
D) None of the above

Question 21

Name two mechanisms playing a critical role in drug transport across skin during iontophoresis.