Question 1

Platinum has two common oxidation states, +2 and +4. Which one is found in effective cancer therapy drugs?&#10;A) +2 only.&#10;B) +4 only.&#10;C) both +2 and +4.

Accepted Answer

Platinum(IV) complexes are used in cancer therapy.

Question 2

Gold has two common oxidation states, +1 and +3. Which one is found in drugs used for treatment of rheumatoid arthritis?&#10;A) +1&#10;B) +3&#10;C) both +1 and +3

Accepted Answer

Gold drugs used for treating rheumatoid arthritis typically involve gold in the +1 oxidation state.

Question 3

Which Bi(III) complexes are commonly used in the treatment of gastric ulcers?&#10;A) Mononuclear Bi(III) complexes with sulfur donor ligands.&#10;B) Polynuclear Bi(III) complexes with sulfur donor ligands.&#10;C) Polynuclear Bi(III) complexes with oxygen donor ligands.

Accepted Answer

C

Question 4

Which lithium compound is used in "lithium therapy" for bipolar disorders? A) LiCl B) LiNO₃ C) LiOH

Accepted Answer

LiCl, or lithium chloride, is the compound used in lithium therapy for treating bipolar disorders. Lithium therapy is a common treatment for stabilizing mood and preventing the extremes of bipolar disorder.

Question 5

What are the CO-releasing drugs used for?&#10;A) Treatment of heavy metal poisoning.&#10;B) Treatment of post-operative stress.&#10;C) As antiviral agents.

Accepted Answer

CO-releasing drugs are used to deliver controlled amounts of carbon monoxide, which has anti-inflammatory and cytoprotective effects, making them useful in managing post-operative stress and other inflammatory conditions.

Question 6

Chelation therapy uses ligands inspired by ___________ in order to treat Fe overload.&#10;A) siderophore structures&#10;B) crown ethers&#10;C) porphyrin rings.

Accepted Answer

Siderophore structures are naturally occurring molecules produced by bacteria to sequester iron from their environment. Chelation therapy for iron overload often uses ligands inspired by these siderophore structures to effectively bind and remove excess iron from the body.

Question 7

Which metals are used in imaging agents?&#10;A) Ga and Ta&#10;B) Gd and Tc&#10;C) Ge and Tl

Accepted Answer

Gadolinium (Gd) and Technetium (Tc) are used in imaging agents. Gadolinium is commonly used in magnetic resonance imaging (MRI) as a contrast agent, and Technetium-99m is widely used in nuclear medicine for a variety of diagnostic tests.

Question 8

Nanoparticles show promise in&#10;A) targeted drug delivery.&#10;B) drug synthesis.&#10;C) treatment of viral diseases.

Accepted Answer

Nanoparticles can be engineered to deliver drugs directly to specific cells or tissues, enhancing the effectiveness and reducing side effects of treatments.

Question 9

Although As₄O₆ is very poisonous compound, it is found in treatment of A) bacterial infections. B) malaria C) one form of leukaemia.

Accepted Answer

The compound As₄O₆, when decoded from the provided format, refers to arsenic trioxide (As2O3). Arsenic trioxide is used in the treatment of a specific type of leukemia known as acute promyelocytic leukemia (APL).

Question 10

What is one of the major challenges in inorganic medicinal chemistry?&#10;A) Understanding the mechanism of action of inorganic compounds.&#10;B) The diverse side-effects of the metallodrugs.&#10;C) The price of metals used in medicine.

Accepted Answer

Understanding the mechanism of action of inorganic compounds is a major challenge in inorganic medicinal chemistry because it is often difficult to determine how inorganic compounds interact with biological systems.

Deck 27: Inorganic Chemistry in Medicine