Question 1

The process by which molecules diffuse from a region of higher concentration to a region of lower concentration and no external energy is expended is called&#10;A)Passive diffusion&#10;B)Active transport&#10;C)Pore transport&#10;D)Facilitation diffusion

Accepted Answer

Passive diffusion is the process where molecules move from an area of higher concentration to an area of lower concentration without the use of external energy.

Question 2

Which law states that 'the rate of diffusion is proportional to both the surface area and concentration difference and is inversely proportional to the thickness of the membrane'?&#10;A)Fick's Law&#10;B)Avagadro's Law&#10;C)Hooke's Law&#10;D)Pascal's Law

Accepted Answer

Fick's Law of Diffusion describes how the rate of diffusion of a substance across a space is proportional to the concentration gradient, the surface area through which diffusion occurs, and inversely proportional to the thickness of the membrane. This law is fundamental in understanding processes such as gas exchange in the lungs.

Question 3

Which of the following is a not mechanism of drug absorption through GIT&#10;A)Pore transport&#10;B)Active transport&#10;C)Endocytosis&#10;D)Metastasis

Accepted Answer

Metastasis refers to the spread of cancer cells from one part of the body to another and is not a mechanism of drug absorption through the gastrointestinal tract (GIT). The other options (pore transport, active transport, and endocytosis) are all mechanisms by which drugs can be absorbed.

Question 4

Which of the following process is also called &#34;cell drinking&#34;?&#10;A)Pinocytosis&#10;B)Phagocytosis&#10;C)Convective transport&#10;D)Active tr

Accepted Answer

Pinocytosis is referred to as "cell drinking" because it involves the ingestion of liquid into a cell by the budding of small vesicles from the cell membrane.

Question 5

The absorption of drugs like (quaternary ammonium compounds, sulphonic acid) are explained by&#10;A)Ion pair transport&#10;B)convective transport&#10;C)active transport&#10;D)Facilitated diffusion

Accepted Answer

Ion pair transport explains the absorption of drugs like quaternary ammonium compounds and sulphonic acid, as these compounds form ion pairs which can cross lipid membranes more easily than the charged species alone.

Question 6

Fick's law is used for study of&#10;A)Dissolution rate&#10;B)Disintegration rate&#10;C)Dissociation rate&#10;D)Diffusion rate

Accepted Answer

Fick's law is primarily used to describe the diffusion rate, which quantifies how substances such as gases, liquids, or solids move from an area of high concentration to an area of low concentration.

Question 7

The delivery of a drug through the skin is known as&#10;A)Sublingual&#10;B)Transdermal&#10;C)Inhalation&#10;D)Buccal

Accepted Answer

Transdermal delivery refers to the administration of medications through the skin, typically using patches that release the drug over time.

Question 8

Which route of drug administration shows 100% Bioavailability?&#10;A)Oral&#10;B)Intravenous&#10;C)Rectal&#10;D)Topical

Accepted Answer

Intravenous (IV) administration delivers the drug directly into the bloodstream, ensuring 100% bioavailability since it bypasses absorption barriers and first-pass metabolism.

Question 9

If drug administered by Intravenous route appears in feaces, it implies that the drug&#10;A)Undergo first pass metabolism&#10;B)Undergoes enterohepatic recycling&#10;C)It is not completely absorbed&#10;D)It is not completely metabolized

Accepted Answer

Enterohepatic recycling refers to the process where drugs or metabolites are excreted into the bile, reabsorbed from the intestine, and returned to the liver. This can lead to the appearance of the drug in feces even if administered intravenously, as part of the drug can be secreted into the bile and then excreted in the feces.

Question 10

Which of the following is characteristic of the oral route?&#10;A)Absorption depends on GI tract secretion and motor function&#10;B)Fast onset of effect&#10;C)A drug reaches the blood passing the liver&#10;D)The sterilization of medicinal forms is obligatory

Accepted Answer

The oral route of drug administration involves absorption that is influenced by gastrointestinal (GI) tract secretions and motor function, affecting how a drug is absorbed into the bloodstream.

Question 11

When the active transport system become saturated, the rate process become&#10;A)Zero order&#10;B)Second order&#10;C)Pseudo first order&#10;D)Pseudo zero order

Accepted Answer

The answer of When the active transport system become saturated,...

Question 12

Rate of absorption of drug by passive diffusion is maximum in&#10;A)Small intestine&#10;B)Large intestine&#10;C)Stomach&#10;D)Oesphagus

Accepted Answer

The answer of Rate of absorption of drug by passive...

Question 13

Maximum movement of drug across the membrane occurs by&#10;A)Completely ionised&#10;B)Unionised&#10;C)Partially ionised&#10;D)None of them

Accepted Answer

The answer of Maximum movement of drug across the membrane...

Question 14

If drug has pKa value of 3 then at pH value of 7 what would be the degree of ionisation of the drug?&#10;A)Majority portion would be ionised&#10;B)Majority portion would be unionised&#10;C)Approximately 50% would be ionised and 50% unionised&#10;D)None of the above

Accepted Answer

The answer of If drug has pKa value of 3...

Question 15

Which of the following is not the characteristic of the carrier mediated transport system?&#10;A)Energy dependent&#10;B)Reach equilibrium&#10;C)Metabolically inhibited&#10;D)Structurally specific and saturable

Accepted Answer

The answer of Which of the following is not the...

Question 16

Which of the following is alimentary route of administration when passage of drug through liver is minimized?&#10;A)Oral&#10;B)Transdermal&#10;C)Rectal&#10;D)Intraduodenal

Accepted Answer

The answer of Which of the following is alimentary route...

Question 17

&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;is the process of movement of unchanged drug from the site of administration to the systemic circulation.&#10;A)Absorption&#10;B)Dissolution&#10;C)Distribution&#10;D)Elimination

Accepted Answer

The answer of &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;is the process of movement of unchanged...

Question 18

Energy is utilized in &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230; diffusion mechanism.&#10;A)Passive&#10;B)Active&#10;C)Pore&#10;D)Cellular

Accepted Answer

The answer of Energy is utilized in &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230; diffusion mechanism.&#10;A)Passive&#10;B)Active&#10;C)Pore&#10;D)Cellular...

Question 19

&#8230;&#8230;&#8230;&#8230;&#8230;&#8230; involves the engulfment of small molecules or fluid.&#10;A)Endocytosis&#10;B)Pinocytosis&#10;C)Phagocytosis&#10;D)None of the above

Accepted Answer

The answer of &#8230;&#8230;&#8230;&#8230;&#8230;&#8230; involves the engulfment of small molecules...

Question 20

The concentration of drug in blood or plasma will be comparatively in the GI tract.&#10;A)High&#10;B)Low&#10;C)Very High&#10;D)Very Low

Accepted Answer

The answer of The concentration of drug in blood or...

Question 21

................mechanism is useful to describe charged or highly ionized drug molecules.&#10;A)Ion-pair transport&#10;B)Cellular transport&#10;C)Active transport&#10;D)Passive tr

Accepted Answer

The answer of ................mechanism is useful to describe charged or...

Question 22

To avoid bioavailability issues, the drug must have a minimum aqueous solubility of&#10;A)150%&#10;B)10%&#10;C)100%&#10;D)1%

Accepted Answer

The answer of To avoid bioavailability issues, the drug must...

Question 23

When the solvent molecules are entrapped in the crystalline structure of the polymorph, it is called as&#10;A)Pseudo-polymorphism&#10;B)Amorphism&#10;C)Crystallinity&#10;D)All of the above

Accepted Answer

The answer of When the solvent molecules are entrapped in...

Question 24

The occurrence of food in the GI tract can affect the drug bioavailability from an oral drug product. The above give statement is?&#10;A)True&#10;B)False&#10;C)Both of the above&#10;D)None of the above

Accepted Answer

The answer of The occurrence of food in the GI...

Deck 1: Pharmaceutical Absorption and Diffusion: Mechanisms and Considerations