Deck 16: Pharmacokinetics of Drug Excretion and Clearance

Question 1

Which of the following is not a factor of renal excretion?

A)Blood flow to the kidneys
B)Urine pH
C)Blood pH
D)Disease state

Answer 1

Blood pH

Question 2

Which of the following is not a physicochemical factor of drug that can affect the renal excretion?

A)Molecular size
B)Disintegration rate
C)pKa of the drug
D)Lipid solubility

Answer 2

Disintegration rate

Question 3

Drugs of molecular range 300-500 Dalton will be excreted out by glomerulus.

A)True
B)False
C)none
D)all

Answer 3

False

Question 4

Clearance is inversely related to volume of distribution.

A)True
B)False
C)none
D)all

Question 5

Which drugs cannot be filtered through glomerulus?

A)Drugs bound to plasma proteins
B)Unbound
C)Free drug
D)Below molecular weight of 300 Dalton

Question 6

Which one is the correct equation to calculate fraction of unbound drug in plasma?

A)Concentration of unbound drug in plasma / total plasma concentration of drug
B)Total plasma concentration of drug / Concentration of unbound drug in plasma
C)1/Concentration of unbound drug in plasma
D)1/total plasma concentration of drug

Question 7

What is total systemic clearance?

A)Sum of clearance from kidney
B)Sum of clearance from kidney and liver
C)Sum of clearance form non-renal clearances
D)Sum of renal and non-renal clearances

Question 8

What is the equation for clearance?

A)Elimination rate / plasma drug concentration
B)Plasma drug concentration/elimination rate
C)1 / Plasma drug concentration
D)1 / Elimination rate

Question 9

What will be the elimination rate if the clearance is 130ml/min and drug concentration is 0.8 g/ml?

A)104g/min
B)140g/min
C)130g/min
D)100g/min

Question 10

What will be the renal clearance if the rate of urinary excretion is 625 ml/min and plasma drug concentration is 4.2 ng/ml?

A)148.80ml2/ng min
B)150ml2/ng min
C)152ml2/ng min
D)140ml2/ng min

Question 11

How renal clearance ratio is expressed?

A)Renal clearance of creatinine / renal clearance of the drug
B)1/renal clearance of the drug
C)Renal clearance of drug/ renal clearance of creatinine
D)1/renal clearance of creatinine

Question 12

What will be the renal clearance ratio of a drug whose renal clearance is 40ml/min and the clearance of creatinine is 95ml/min?

A)0.421
B)2.38
C)0.010
D)0.025

Question 13

How do you calculate the rate of excretion by kidneys?

A)Rate of filtration - the rate of secretion - Rate of absorption
B)Rate of filtration + rate of secretion - Rate of absorption
C)Rate of filtration + rate of secretion + Rate of absorption
D)Rate of filtration - the rate of secretion + Rate of absorption

Question 14

What will be the rate of filtration if the rate of secretion is 0.9 ml/ sec, rate of reabsorption is 0.2 ml/sec and the rate of excretion is 2ml/sec for a particular drug?

A)3ml/sec
B)0.3ml/sec
C)1ml/sec
D)1.3ml/sec

Question 15

Which one of the following is the principal organ for drug excretion?

A)Lungs
B)Liver
C)Kidneys
D)Sweat glands

Question 16

Compounds excreted in bile is classified into 3 categories. Which one of the following does not come under the categories?

A)Drugs with bile/plasma concentration ratio approximately 1
B)Drugs with bile/plasma concentration ratio between 10-1000
C)Drugs with bile/plasma concentration ratio of less than 1
D)Drugs with bile/plasma concentration ratio above 1000

Question 17

What is the molecular weight cut off for biliary excretion?

A)Less than 300 Dalton
B)More than 300 Dalton
C)Less than 200 Dalton
D)More than 200 Dalton

Question 18

What is the equation for biliary clearance?

A)No such equation is there
B)Biliary excretion rate/ plasma drug concentration
C)Plasma drug concentration / biliary excretion rate
D)Plasma drug concentration / Bile flow * biliary drug concentration

Question 19

For a certain drug, the bile flow rate is 0.7 ml/mm, the biliary drug concentration is 2g/ml and the plasma drug concentration is 0.8g/ml. What will be the bile clearance?

A)1.50 ml/mm
B)1.75 ml/mm
C)2.75 ml/mm
D)3 ml/mm

Question 20

Which compounds are excreted through the lungs?

A)Lipophilic
B)Gaseous
C)Liquid and hydrophilic
D)Solid less than 100 Dalton

Question 21

What is the pH of the milk secreted by human mothers?

A)6.4-7.6
B)5.4-6.6
C)7-8
D)6-7

Question 22

What is the mechanism of drug excretion for skin excretion?

A)Active secretion
B)Glomerular secretion
C)Passive diffusion
D)Passive reabsorption

Question 23

What is the mechanism of drug excretion for biliary excretion?

A)Active secretion
B)Glomerular secretion
C)Passive diffusion
D)Passive reabsorption

Question 24

Which of the following is not a factor influencing pulmonary excretion?

A)Pulmonary blood flow
B)The solubility of volatile substance
C)Rate of respiration
D)Heart rate

Question 25

How is renal clearance expressed mathematically?

A)Rate of urinary excretion/plasma drug concentration
B)Plasma drug concentration/rate of urinary excretion
C)1/ Plasma drug concentration
D)1/rate of urinary excretion