Question 1

The ratio of maximum safe concentration to minimum effective concentration is called as&#10;A)Therapeutic index&#10;B)Therapeutic range&#10;C)Therapeutic outcome&#10;D)Therapeutic ratio

Accepted Answer

The therapeutic index is a measure of the safety of a drug, calculated as the ratio between the toxic dose and the therapeutic dose. It indicates the margin of safety of a drug, with a higher index suggesting a greater margin between effective and toxic doses.

Question 2

Half life of zero-order process is proportional to of drug.&#10;A)initial concentration&#10;B)final concentration&#10;C)both (a) & (b)&#10;D)none of the above

Accepted Answer

The half-life of a zero-order process is directly proportional to the initial concentration of the drug, meaning as the initial concentration increases, the half-life also increases. This is because in a zero-order process, the rate of reaction is constant and does not depend on the concentration of the reactant.

Question 3

The ability of liver to excrete drug in bile is expressed by&#8230;&#8230;&#8230;&#10;A)hepatic clearance&#10;B)biliary clearance&#10;C)non-renal clearance&#10;D)renal clearance

Accepted Answer

Biliary clearance specifically refers to the process by which the liver excretes drugs into the bile, a part of the digestive system. This is distinct from hepatic clearance, which encompasses all processes by which the liver removes drugs from the blood, including metabolism and excretion into bile.

Question 4

&#8230;&#8230;&#8230;&#8230;..is nothing but manner in which drug should be taken.&#10;A)dosing frequency&#10;B)dosage regimen&#10;C)dose adjustment&#10;D)none of the above

Accepted Answer

A dosage regimen is the manner in which a drug should be taken, including the dose, frequency, and duration of administration.

Question 5

What is dosage regimen?&#10;A)The concentration of active agent in the drug formulation&#10;B)The manner in which the drug is given to old people&#10;C)The manner in which a drug is taken&#10;D)The manner in which drug given to child

Accepted Answer

The dosage regimen refers to the schedule of doses of a drug, including the amount, frequency, and duration of administration. It is not specific to any age group and encompasses the overall plan for drug intake to achieve therapeutic effects.

Question 6

What is optimal multiple dosage regimen?&#10;A)The concentration of active agent in the drug formulation&#10;B)Dosage which maintains the plasma concentration within the therapeutic window.&#10;C)The manner in which a drug is taken&#10;D)The manner in which drug given to child

Accepted Answer

The optimal multiple dosage regimen is designed to maintain the plasma concentration of a drug within the therapeutic window, ensuring it is effective without being toxic.

Question 7

On what basis the dose interval is calculated?&#10;A)Active drug concentration in the formulation&#10;B)Half-life of the drug&#10;C)Duration of the disease&#10;D)Age of the patient

Accepted Answer

The dose interval is primarily calculated based on the half-life of the drug, which is the time it takes for the concentration of the drug in the body to reduce to half its initial value. This helps in maintaining effective drug levels in the body.

Question 8

What is fluctuation?&#10;A)Cmax/Cmin&#10;B)Cmin / Cmax&#10;C)1/Cmin&#10;D)1/Cmax

Accepted Answer

Fluctuation is defined as the ratio of the maximum concentration (Cmax) to the minimum concentration (Cmin) of a substance in the body over a specific period, typically used to describe the variation in blood levels of a drug following administration.

Question 9

How do you calculate the ideal body weight for men?&#10;A)50 kg +- 1kg/2.5cm above or below 150 cm in height&#10;B)45 kg +- 1kg/2.5cm above or below 150 cm in height&#10;C)40 kg +- 1kg/2.5cm above or below 150 cm in height&#10;D)35 kg +- 1kg/2.5cm above or below 150 cm in height

Accepted Answer

The ideal body weight for men is calculated using the formula: 50 kg for the first 150 cm of height, plus an additional 1 kg for every 2.5 cm above or below 150 cm. This method is known as the Devine formula.

Question 10

How do you calculate the ideal body weight for a woman?&#10;A)50 kg +- 1kg/2.5cm above or below 150 cm in height&#10;B)45 kg +- 1kg/2.5cm above or below 150 cm in height&#10;C)40 kg +- 1kg/2.5cm above or below 150 cm in height&#10;D)35 kg +- 1kg/2.5cm above or below 150 cm in height

Accepted Answer

The ideal body weight for a woman is calculated as 45 kg for the first 150 cm of height, with an additional 1 kg for every 2.5 cm above or below 150 cm. This formula is a common method used in healthcare to estimate a healthy weight.

Question 11

Which of the following drugs are lipid soluble?&#10;A)Phenytoin&#10;B)Caffeine&#10;C)Digoxin&#10;D)Antibiotics

Accepted Answer

The answer of Which of the following drugs are lipid...

Question 12

Which of the following drugs get distributed to the same extent in both lean and adipose tissue?&#10;A)Phenytoin&#10;B)Caffeine&#10;C)Digoxin&#10;D)Antibiotics

Accepted Answer

The answer of Which of the following drugs get distributed...

Question 13

Which of the following drugs can get distributed to the excess body space of obese patient?&#10;A)Phenytoin&#10;B)Caffeine&#10;C)Digoxin&#10;D)Antibiotics

Accepted Answer

The answer of Which of the following drugs can get...

Question 14

Which of the following drug can get distributed in the excess body space?&#10;A)Phenytoin&#10;B)Caffeine&#10;C)Digoxin&#10;D)Antibiotics

Accepted Answer

The answer of Which of the following drug can get...

Question 15

Neonates, infants and children require different dosages than adults.&#10;A)True&#10;B)False&#10;C)none&#10;D)all

Accepted Answer

The answer of Neonates, infants and children require different dosages...

Question 16

Accumulation occurs because drug from previous doses was not being removed completely.&#10;A)True&#10;B)False&#10;C)none&#10;D)all

Accepted Answer

The answer of Accumulation occurs because drug from previous doses...

Question 17

The renal clearance of a drug bound to plasma protein is increased after displacement with another drug.&#10;A)True&#10;B)False&#10;C)none&#10;D)all

Accepted Answer

The answer of The renal clearance of a drug bound...

Question 18

Which of the following promotes excretion of acidic drugs?&#10;A)Citrates&#10;B)Ammonium chloride&#10;C)Methionine&#10;D)Ascorbic acid

Accepted Answer

The answer of Which of the following promotes excretion of...

Question 19

Which of the following promotes the excretion of basic drugs?&#10;A)Tartarates&#10;B)Citrates&#10;C)Bicarbonates&#10;D)Ammonium chloride

Accepted Answer

The answer of Which of the following promotes the excretion...

Question 20

This is the equation for the calculation of creatinine clearance. Which age group does the Clcr = 0.48 H / Scr *[W/70]0.7 formula belong to?&#10;A)1-6 years&#10;B)1-20 years&#10;C)Males above 20 years&#10;D)Females above 20 years

Accepted Answer

The answer of This is the equation for the calculation...

Question 21

This is the equation for the calculation of creatinine clearance. Which age group does the Clcr = (140 - Age) W / 72 * Scr formula belong to?&#10;A)1-6 years&#10;B)1-20 years&#10;C)Males above 20 years&#10;D)Females above 20 years

Accepted Answer

The answer of This is the equation for the calculation...

Question 22

This is the equation for the calculation of creatinine clearance. Which age group does the Clcr = (140 - Age) W / 85 * Scr formula belong to?&#10;A)1-6 years&#10;B)1-20 years&#10;C)Males above 20 years&#10;D)Females above 20 years

Accepted Answer

The answer of This is the equation for the calculation...

Question 23

A girl with age 21 has height 240cm, weight 55kg, serum creatinine of 0.8mg will have ______________ creatinine clearance.&#10;A)80 ml/min&#10;B)90 ml/min&#10;C)96.25 ml/min&#10;D)85 ml/min

Accepted Answer

The answer of A girl with age 21 has height...

Question 24

An adult male with age 22 has height 240cm, weight 85kg, serum creatinine of 0.8mg will have ______________ creatinine clearance.&#10;A)150 ml/min&#10;B)160 ml/min&#10;C)170.13 ml/min&#10;D)174.131 ml/min

Accepted Answer

The answer of An adult male with age 22 has...

Question 25

Which creatinine clearance value shows moderate renal failure?&#10;A)120-130 ml/min&#10;B)20-50 ml/min&#10;C)Below 10 ml/min&#10;D)70-80 ml/min

Accepted Answer

The answer of Which creatinine clearance value shows moderate renal...

Deck 22: Pharmacokinetics and Dosage Regimen