Deck 19: Sedative-Hypnotic and Anxiolytic Drugs

Question 1

Which property is related to the ability of zolpidem to selectively bind GABAA receptors that are composed of α ₁-subunits?

A) lack of active metabolites
B) low degree of daytime sedation
C) low potential for drug dependence
D) greater effect on REM sleep
E) greater effect on slow wave sleep

Answer 1

low potential for drug dependence

Question 2

Which attribute is correctly associated with ramelteon?

A) produces considerable daytime sedation
B) may cause rebound insomnia when discontinued
C) has a high abuse potential
D) binds melatonin receptors
E) is a Schedule IV controlled substance

Answer 2

binds melatonin receptors

Question 3

For which reason is lorazepam is one of the safer benzodiazepines for elderly patients?

A) It is excreted unchanged in the urine.
B) It does not cause anterograde amnesia.
C) It is not associated with drug dependence.
D) It is metabolized by glucuronide formation.
E) It has special utility in treating panic disorder.

Answer 3

It is metabolized by glucuronide formation.

Question 4

Because of its ability to induce α-aminolevulinate synthase, phenobarbital should not be taken in persons with which disorder?

A) porphyria
B) homocystinuria
C) pernicious anemia
D) hemophilia
E) hepatitis