Deck 22: Antineoplastic Agents

Question 1

Which of the following are essential regulators of normal cellular functions?

A) carcinogenic agents
B) protooncogenes
C) tumor suppressor genes
D) oncogenes

Answer 1

protooncogenes

Question 2

The trade name of melphalan is:

A) Mustargen
B) Thiotepa
C) Ifex
D) Alkeran

Answer 2

Alkeran

Question 3

Which of the following is NOT an alkylating agent?

A) Mustargen
B) Hexalen
C) Xeloda
D) Cytoxan

Answer 3

Xeloda

Question 4

The trade name for busulfan is:

A) Leukeran
B) Mustargen
C) Busulfex
D) Blenoxane

Question 5

Which of the following is NOT an antitumor antibiotic?

A) Blenoxane
B) Vinblastine
C) Adriamycin
D) Cerubidine

Question 6

Which of the following is classified as a plant alkaloid?

A) vincristine (Vincasar PFS)
B) methotrexate (Trexall)
C) mercaptopurine (Purinethol)
D) bleomycin (Blenoxane)

Question 7

Mitotic inhibitors are referred to as which of the following?

A) alkyl sulfonates
B) antitumor antibiotics
C) antimetabolites
D) plant alkaloids

Question 8

The trade name of teniposide is:

A) Vinblastine
B) Vumon
C) Navelbine
D) Matulane

Question 9

A palliative treatment is one that:

A) develops from normal genes
B) arises from glandular origin
C) eases a disease's effects
D) aids or contributes

Question 10

Which of the following antimetabolites is administered intravenously?

A) fluorouracil (Adrucil)
B) procarbazine (Matulane)
C) mercaptopurine (Purinethol)
D) capecitabine (Xeloda)

Question 11

The trade name of estramustine is:

A) Zoladex
B) Eligard
C) Emcyt
D) Megace

Question 12

Mercaptopurine is useful in the maintenance therapy of children with:

A) myelocytic leukemia
B) ovarian cancer
C) brain cancer
D) lung cancer

Question 13

Doxorubicin is used to treat which of the following cancers?

A) breast and ovarian
B) Kaposi's sarcoma and Wilms' tumor
C) testicular and urinary bladder
D) skin and brain cancer

Question 14

The normal function of tumor suppressor genes is to:

A) regulate and inhibit inappropriate cellular growth and proliferation
B) cause gene mutation
C) shed neoplastic cells
D) split cells into new cells

Question 15

Chemotherapy kills cancer cells because of its ability to:

A) synthesize RNA
B) synthesize DNA
C) stop cell division
D) increase cell division

Question 16

The final step of the cell cycle, when the cell splits into two new cells, is known as:

A) DNA synthesis
B) mitosis
C) resting stage
D) gap phase

Question 17

Basic structural subunits of DNA whose precise sequencing encodes the DNA are known as:

A) nitrosoureas
B) cell-cycle phase specific agents
C) tumor cells
D) nucleotides

Question 18

The treatment of choice for many solid tumors is:

A) surgery
B) radiation
C) chemotherapy
D) immunotherapy

Question 19

Alkylating agents cause hydrogen replacement by an alkyl group, specifically one that inhibits cell division and growth. The five major types of alkylating agents include nitrogen mustards and all the following except:

A) ethyleneimines
B) nitrosoureas
C) triazenes
D) antimetabolites

Question 20

Most alkylating agents cause:

A) paralysis
B) alopecia (hair loss)
C) constipation
D) generalized seizures

Question 21

Alkylating agents are able to cause birth defects in fetuses, which is described by the term:

A) keratosis
B) veno-occlusive
C) teratogenic
D) carcinogenic

Question 22

Antimetabolites prevent cancer cell growth by affecting:

A) DNA production
B) RNA production
C) WBC production
D) RBC production

Question 23

Which of the following hormones is used to treat prostate cancer?

A) estrogen
B) androgen
C) progestin
D) testosterone

Question 24

The trade name of flutamide is:

A) Casodex
B) Zoladex
C) Eulexin
D) Nilandron

Question 25

Make sure patients understand that mitotic inhibitors may produce serious toxicity with GI damage and:

A) increased bone formation
B) the migration of WBCs
C) bone-marrow depression
D) blocked hormone action

Question 26

To treat carcinomas of the reproductive tract, which of the following is/are used?

A) Arachidonic acid
B) Sex hormones
C) White blood cells
D) Antitumor antibiotics

Question 27

Cancer treatments made from natural products produced by Streptomyces are known as:

A) interferons
B) biologic-response modifiers
C) antitumor antibiotics
D) hormonal agents

Question 28

The trade name of leuprolide is:

A) Casodex
B) Eligard
C) Emcyt
D) Nolvadex

Question 29

Busulfex (busulfan) is known as:

A) a mitotic inhibitor
B) a plant alkaloid
C) an alkyl sulfonate
D) an antitumor antibiotic