Deck 11: Component Therapy and Massive Transfusion

Question 1

Which of the following modifications can help to prevent the formation of antibodies to HLA antigens?

A)Freezing
B)Irradiation
C)Leukoreduction
D)Washing

Answer 1

Leukoreduction

Question 2

Patients rarely need red blood cell transfusions if the hemoglobin concentration is

A)Below 7 g/dL (70 g/L)and the patient has a low oxygen saturation level
B)Below 10 g/dL (100 g/L)and the patient is bleeding
C)Between 7 and 10 g/dL (70 and 100 g/L)and the patient has underlying cardiac disease
D)Above 10 g/dL (100 g/L)and the patient is hemodynamically stable

Answer 2

Above 10 g/dL (100 g/L)and the patient is hemodynamically stable

Question 3

Autologous hematopoietic progenitor cells (HPCs)are collected from the patient's bone marrow or peripheral blood after

A)High doses of chemotherapy
B)Low doses of chemotherapy
C)High doses of 10% DMSO
D)Low doses of 10% DMSO

Answer 3

Low doses of chemotherapy

Question 4

Which of the following is not a benefit to using fresh frozen plasma?

A)Helps prevent bleeding due to coagulopathy
B)Improves hemostasis
C)Provides all coagulation factors
D)Provides functional platelets

Question 5

All the following are true about RhIg except

A)Can be used in some cases as an alternative to IVIG
B)Contributes to fluid balance both within the blood vessels and throughout the body
C)Is administered to prevent immunization to the D antigen
D)Is often administered intramuscularly when given in the perinatal or postnatal period

Question 6

Which of the following is most commonly used as a volume replacement in trauma,shock,burns,and therapeutic plasma exchange?

A)Albumin
B)Fibrinogen
C)Globulin
D)Lipoprotein

Question 7

What gauge of needle is typically used for blood transfusions?

A)18
B)21
C)23
D)25

Question 8

Which of the following is the first treatment step in responding to massive blood loss?

A)Establish an intravenous access
B)Infuse colloid solutions
C)Improve oxygen delivery
D)Restore circulating systemic volume

Question 9

Where do the majority of hematopoietic progenitor cells (HPCs)reside?

A)bone marrow
B)lymphatic system
C)peripheral circulation
D)striated muscle

Question 10

Cryoprecipitate contains which coagulation factors?

A)Factor V,factor VII,factor VIII
B)Factor VII,factor VIII,factor XIII
C)Fibrinogen,factor V,factor VIII
D)Fibrinogen,factor VIII,factor XIII

Question 11

Which of the following can be used to stimulate platelet production in patients suffering from bone marrow suppression that has caused thrombocytopenia?

A)G-CSF
B)GM-CSF
C)Recombinant EPO
D)Recombinant TPO

Question 12

All of the following statements are true of intraoperative blood salvage except

A)Bacteria at the site of the surgery are washed out of the blood before reinfusion.
B)Blood can be collected during or after surgery.
C)Collected blood can be reinfused as either whole blood or red blood cells.
D)Collected blood is mixed with anticoagulant.

Question 13

A platelet count of less than _____ is often used as a trigger to initiate prophylactic platelet transfusions to prevent intracranial hemorrhage.

A)10 × 10³ / µL (10 x 10⁹/L)
B)20 × 10³ / µL (20 x 10⁹/L)
C)30 × 10³ / µL (30 x 10⁹/L)
D)40 × 10³ / µL (40 x 10⁹/L)

Question 14

Which of the following do hematopoietic progenitor cell (HPC)donors routinely receive prior to donation?

A)Desmopressin
B)G-CSF
C)Recombinant EPO
D)Recombinant TPO

Question 15

Community-directed donation programs are often used to find donors for patients suffering from one of which two diseases?

A)Anemia or coagulopathy
B)Hemophilia A or hemophilia B
C)Leukemia or lymphoma
D)Sickle cell anemia or thalassemia

Question 16

The infusions of all blood components should occur in less than ___ hours.

A)2
B)3
C)4
D)5

Question 17

Whole blood transfusion achieves all of the following except

A)Improved cellular immune function
B)Improved tissue oxygenation
C)Replacement of fluid
D)Replacement of nonlabile coagulation factors

Question 18

Which method might be used to decrease the risk of transfusion-associated cytomegalovirus (CMV)transmission?

A)Freezing
B)Irradiation
C)Leukoreduction
D)Washing

Question 19

Which of the following is used as a presurgical prophylaxis to reduce or prevent bleeding in patients with mild hemophilia A?

A)Desmopressin
B)G-CSF
C)Vitamin K
D)Recombinant EPO

Question 20

Which statement is true regarding granulocyte transfusion?

A)Is used primarily as interim therapy for patients who expect to recover neutrophil production.
B)Is first-line therapy for patients with bacterial or fungal sepsis.
C)May be acceptable to some patients who refuse other blood transfusions for religious reasons.
D)May use an autologous blood component.