Deck 5: Rh, Rhag, and Lw Blood Group Systems

Question 1

Which of the following is not true about Cw antigen?

A)Antithetical to the high-incidence antigen MAR
B)Common in people of African ethnicity
C)May be present with C and c antigens
D)Originally thought to be an allele of the C/c locus

Answer 1

Common in people of African ethnicity

Question 2

The C/c antigens arise from a single amino acid difference at position

A)10³
B)215
C)226
D)302

Answer 2

10³

Question 3

The RHD gene codes for the ____ antigen.

A)A
B)B
C)C
D)D

Answer 3

D

Question 4

When testing for weak D using an indirect antigblobulin test (IAT),cells that are already coated with _____ can give a false-positive reaction in the antiglobulin phase.

A)IgA
B)IgD
C)IgE
D)IgG

Question 5

Which chromosome carries the two Rh genes?

A)1
B)6
C)7
D)9

Question 6

In people of European ethnicity,the most common Rh(D)-positive phenotype is ___ and the most common Rh(D)-negative phenotype is ____.

A)R1R1,r'r'
B)R2R2,r''r''
C)R1R2,r'r''
D)R1r,rr

Question 7

Which of the following is a purified concentrate of human anti-D?

A)HBIg
B)RhIg
C)Rhmod
D)Rhvariable

Question 8

Donor red blood cells that are e negative will be ______,unless they are of a rare deletion phenotype.

A)c negative
B)c positive
C)E negative
D)E positive

Question 9

Rh antibodies may develop in response to transfusion of which of the following blood products?

A)Cryoprecipitate
B)Platelets
C)Rh-immune globulin
D)Thawed plasma

Question 10

The absence of the D antigen occurs most commonly when the

A)RHCE gene is deleted
B)RHCE gene is present
C)RHD gene is deleted
D)RHD gene is present

Question 11

Which antigen is routinely tested for in all blood donors and recipients in most countries?

A)C
B)D
C)E
D)O

Question 12

When both c and e antigens are present on the red blood cell membrane and the respective genes are in the cis position or on the same chromosome,which antigen is expressed?

A)Ce
B)d
C)f
D)G

Question 13

Which of the following is not true about Rh proteins?

A)One amino acid is responsible for the difference between the C and c antigens.
B)RhD and RhCE proteins have the same composition except for 33-35 amino acids.
C)Rh proteins are nonglycosylated.
D)There is one carbohydrate molecule attached to the Rh proteins.

Question 14

Clonal reagent anti-D may be

A)IgD or IgG
B)IgE or IgG
C)IgE or IgM or blend of both
D)IgG or IgM or blend of both

Question 15

Molecular studies have shown that most ____ D phenotypes are due to an exchange of genetic information between RHD and RHCE genes.

A)modified
B)null
C)partial
D)weak

Question 16

The Ce antigen is present when C and e are found in the ____ position.

A)cis
B)co-dominant
C)null
D)trans

Question 17

All of the following are frequently encountered Rh antibodies in the transfusion service except

A)Anti-D
B)Anti-c
C)Anti-ce
D)Anti-E

Question 18

The way that anti-D reagents were historically formulated to allow agglutination without the antiglobulin phase was to add what percentage of protein?

A)5-10%
B)10-20%
C)20-24%
D)22-30%

Question 19

If rouLeᵃux is suspected as being the cause of a positive Rh control in the immediate spin phase,what action should be taken?

A)Incubate the test and control at 39.2° F (4° C)for 10 minutes
B)Incubate the test and control at 98.6° F (37° C)for 15 minutes
C)Repeat the test and control using saline washed red blood cells
D)Repeat the test and control using warmed red blood cells

Question 20

What animal was the Rhesus blood group system named after?

A)Guinea pig
B)Monkey
C)Rabbit
D)Squirrel