Deck 26: Therapeutic Agents for the Hematologic System

Question 1

Granulocytopenia is a reduction in the number of:

A)Neutrophils
B)Eosinophils
C)Basophils
D)All of the above

Answer 1

D
Granulocytopenia is a reduction in the number of granulocytes, which encompasses specific types of white blood cells in the blood that contain granules. These white blood cells include neutrophils, eosinophils, and basophils; all are known as granulocytes.

Question 2

Idiopathic thrombocytopenia is caused by:

A)Pregnancy
B)Drugs
C)Bleeding
D)Unknown factors

Answer 2

D
Some of the most common causes are pregnancy (gestational thrombocytopenia), drug side effects (drug-induced thrombocytopenia), and idiopathic thrombocytopenia. Idiopathic means of unknown cause.

Question 3

Antimetabolite agents:

A)Work by interfering with cancer cell reproduction.
B)Have extreme side effects.
C)Are often used to treat leukemia.
D)All of the above are characteristics of antimetabolites.

Answer 3

D
The structure of antimetabolites is similar to that of the bases in the nucleotides that form deoxyribonucleic acid (DNA) strands; however, because they are not identical, antimetabolites prevent the completion of cell division or mitosis. Antimetabolites are often used to treat leukemia. The most common side effects include nausea, vomiting, fever, anorexia, bone marrow suppression, and jaundice.

Question 4

Which one of the following generics is not an antibiotic used in chemotherapy?

A)Bleomycin
B)Cyclophosphamide
C)Mitomycin
D)Daunorubicin

Question 5

Which of the following blood components is essential to clotting?

A)Albumin
B)Plasma
C)Platelets
D)Erythrocytes

Question 6

Which type of anemia is caused by a vitamin B₁₂ deficiency attributable to congenital or acquired deficiency of intrinsic factor (IF)?

A)Folate-deficiency anemia
B)Iron-deficiency anemia
C)Pernicious anemia
D)Sickle cell anemia

Question 7

Which of the following categories of chemotherapeutic agents can cross the blood-brain barrier to reach cancers of the brain?

A)Antibiotics
B)Nitrosoureas
C)Antimetabolites
D)Nitrogen mustards

Question 8

Which of the following statements is(are) true regarding erythrocytes?

A)Erythrocytes are red blood cells (RBCs).
B)They contain hemoglobin.
C)They fight infection.
D)Erythrocytes are RBCs that contain hemoglobin.

Question 9

Which of the following is(are) functions of the blood?

A)Carrying waste from tissues and organs
B)Delivering oxygen and nutrients to tissues and organs
C)Transporting immune cells to sites of infection and injury
D)All of the above

Question 10

Which of the following statements is(are) true of filgrastim (Neupogen)?

A)Filgrastim is administered orally.
B)It should not be shaken before administering.
C)Filgrastim is used to treat neutropenia.
D)B and C are true statements.

Question 11

The combination therapies of adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) and mustard, oncovin , procarbazine, and prednisone (MOPP) are commonly used for:

A)Chronic lymphocytic leukemia
B)Chronic myeloid leukemia
C)Acute lymphoblastic leukemia
D)Hodgkin disease

Question 12

Eltrombopag (Promacta) for the treatment of thrombocytopenia increases ______________ production.

A)White blood cell
B)Platelet
C)RBC
D)Albumin

Question 13

What is the primary treatment for iron-deficiency anemia?

A)Spinach
B)Blood transfusions
C)Oral iron supplements
D)Intravenous (IV) iron

Question 14

What is the term for an increase in the total cell mass of the blood?

A)Erythropoiesis
B)Hemophilia
C)Polycythemia
D)Leukopenia

Question 15

Erythropoietin:

A)Is a hormone produced by the kidney.
B)Stimulates RBC production.
C)Can be used to treat some types of anemia.
D)All of the above are characteristics of erythropoietin.

Question 16

Low albumin concentration in the blood can lead to:

A)Hypertension
B)Edema
C)Hypotension
D)Hyperproteinemia

Question 17

What element is necessary for the production of hemoglobin?

A)Sodium
B)Potassium
C)Iron
D)Zinc

Question 18

In which form of anemia do RBCs take on an abnormal shape?

A)Folate-deficiency anemia
B)Iron-deficiency anemia
C)Pernicious anemia
D)Sickle cell anemia

Question 19

Which of the following medications are not associated with drug-induced thrombocytopenia (low platelet count)?

A)Heparin
B)Vancomycin
C)Phenytoin
D)All of the above

Question 20

Which category of chemotherapy medications is a group of alkaloids derived from plants?

A)Mitotic inhibitors
B)Antibiotics
C)Alkylating agents
D)Nitrosoureas

Question 21

Side effects of iron therapy may include:

A)Nausea and vomiting
B)Constipation
C)Dark stools
D)All of the above

Question 22

Leukemia involves the production of:

A)High number of cancerous stem cells that replace normal white blood cells in the bone marrow
B)Large number of RBCs
C)Too many platelets
D)Too much albumin

Question 23

Eltrombopag (Promacta) for thrombocytopenia requires which one of the following auxiliary labels?

A)Take on an empty stomach.
B)Take with food or milk.
C)Take at least 1 hour before or 2 hours after meals.
D)Take on an empty stomach at least 1 hour before or 2 hours after meals.

Question 24

Which of the following statements is(are) true regarding the use of warfarin?

A)Avoid aspirin and nonsteroidal antiinflammatory drugs (NSAIDs).
B)Eat extra foods containing vitamin K.
C)Occasionally skipping a dose is okay.
D)A and B are true statements.

Question 25

Which of the following is not considered a granulocyte?

A)Lymphocyte
B)Neutrophil
C)Eosinophil
D)Basophil

Question 26

The generic name for Feosol is:

A)Iron polysaccharide
B)Ferrous sulfate
C)Ferrous gluconate
D)Ferrous fumarate

Question 27

Desmopressin (DDAVP) is available in all of the following dosage forms except:

A)IV and subcutaneous
B)Topical
C)Intranasal
D)Oral

Question 28

The treatment for polycythemia vera can include:

A)Phlebotomy
B)Hydroxyurea
C)Erythropoietin
D)A and B

Question 29

Which one of the following statements is true concerning leukemia?

A)Leukemia is a genetic disorder.
B)It is caused by environmental factors.
C)Both genetic and environmental factors can contribute to the development of leukemia.
D)Leukemia is contagious.

Question 30

Stage _____ of cancer is the most advanced form.

A)I
B)II
C)III
D)IV

Question 31

DDAVP increases plasma factor VIII and von Willebrand factor and is used to treat:

A)von Willebrand disease
B)Hemophilia A
C)Surgical bleeding
D)All of the above