Deck 15: Treatment of Autoimmune Diseases That Affect the Musculoskeletal System

Question 1

Which of the following is not considered and autoimmune disease?

A)myasthenia gravis
B)multiple sclerosis
C)type 2 diabetes
D)systemic lupus erythematosus

Answer 1

D
Myasthenia gravis,multiple sclerosis,rheumatoid arthritis,and systemic lupus erythematosus are examples of autoimmune diseases that affect musculoskeletal system.

Question 2

In myasthenia gravis,the body attacks and destroys receptor sites in the neuromuscular junction that bind _____.

A)dopamine
B)norepinephrine
C)acetylcholine
D)GABA

Answer 2

C
In myasthenia gravis,the body attacks and destroys receptor sites in the neuromuscular junction that bind acetylcholine.

Question 3

All of the following are true about the pharmacokinetics of glucocorticoids used in the treatment of multiple sclerosis,myasthenia gravis,systemic lupus erythematosus,myositis,and rheumatoid arthritis except _____.

A)the absorption,distribution,metabolism,and elimination of glucocorticoids vary according to the dosage form administered
B)in general,oral dosage forms are well absorbed in the gastrointestinal tract and are readily distributed
C)there are very few adverse effects
D)metabolism occurs in the liver

Answer 3

C
The absorption,distribution,metabolism,and elimination of glucocorticoids used in the treatment of multiple sclerosis,myasthenia gravis,systemic lupus erythematosus,myositis,and rheumatoid arthritis vary according to the dosage form administered.In general,oral dosage forms are well absorbed in the gastrointestinal tract and are readily distributed.Metabolism occurs in the liver and they are eliminated by the kidneys in urine.The adverse effects produced by glucocorticosteroids are numerous and affect all body systems.

Question 4

All of the following autoimmune diseases affect the muscles except _____.

A)systemic lupus erythematosus
B)dermatomyositis
C)myasthenia gravis
D)polymyositis

Question 5

MATCHING
Match the following drugs with their drug classes.
a.interleukin antagonist
b.NSAID
c.tumor necrosis factor inhibitor
d.disease-modifying antirheumatic drug
e.antimalarial
f.immunosuppressive
g.glucocorticoid
chloroquine

Question 6

Immunosuppressive drugs work by _____.

A)interfering with the formation of immune cells
B)damaging RNA and DNA needed for replication
C)a and b
D)none of the above

Question 7

Drug therapy for autoimmune diseases is aimed at suppressing _____.

A)inflammation
B)pain
C)immune system response
D)all of the above

Question 8

_____ is more toxic than most of the drugs used in the treatment of rheumatoid arthritis,systemic lupus erythematosus,myasthenia gravis,and multiple sclerosis,so its use is reserved for severe,active disease.

A)Dexamethasone
B)Cyclophosphamide
C)Prednisone
D)Chloroquine

Question 9

MATCHING
Match the following drugs with their drug classes.
a.interleukin antagonist
b.NSAID
c.tumor necrosis factor inhibitor
d.disease-modifying antirheumatic drug
e.antimalarial
f.immunosuppressive
g.glucocorticoid
anakinra

Question 10

Which class of medication is prescribed commonly to suppress inflammation,reduce flare-ups,and treat pain associated with multiple sclerosis,myasthenia gravis,systemic,erythematosus myositis,and rheumatoid arthritis?

A)antibiotics
B)glucocorticoids
C)antivirals
D)mineralocorticoids

Question 11

MATCHING
Match the following drugs with their drug classes.
a.interleukin antagonist
b.NSAID
c.tumor necrosis factor inhibitor
d.disease-modifying antirheumatic drug
e.antimalarial
f.immunosuppressive
g.glucocorticoid
Celoxib

Question 12

Aspirin and NSAIDs work by blocking the activity of the enzyme _____.

A)monoamine oxidase
B)cyclooxygenase
C)streptokinase
D)cytochrome P450

Question 13

Glucocorticosteroids work by _____.

A)suppressing the immune system actions
B)inhibiting the synthesis of antibodies that are responsible for attacking the body's healthy cells
C)increasing levels of antinuclear antibody
D)a and b

Question 14

_____ in used in the treatment of multiple sclerosis and interferes with DNA repair and RNA synthesis,which effectively reduces the growth and spread of immune cells and therefore decreases the progression of the disease.It is also prescribed for the treatment of leukemia,breast and prostate cancer,and pediatric sarcoma.

A)Mitoxantrone
B)Hydroxychloroquine
C)Cyclosporine
D)Betamethasone

Question 15

MATCHING
Match the following drugs with their drug classes.
a.interleukin antagonist
b.NSAID
c.tumor necrosis factor inhibitor
d.disease-modifying antirheumatic drug
e.antimalarial
f.immunosuppressive
g.glucocorticoid
methylprednisolone

Question 16

MATCHING
Match the following drugs with their drug classes.
a.interleukin antagonist
b.NSAID
c.tumor necrosis factor inhibitor
d.disease-modifying antirheumatic drug
e.antimalarial
f.immunosuppressive
g.glucocorticoid
cyclosporine

Question 17

_____ levels are elevated in people that have systemic lupus erythematosus.

A)Antinuclear antibody (ANA)
B)Rheumatoid factor
C)Protein specific antigen
D)Adrenocorticotropic hormone

Question 18

An autoimmune disease occurs when the _____.

A)immune system turns against the parts of the body it is designed to protect
B)body attacks its own cells,thinking they are germs or a harmful substance
C)body manufactures cells to replace the ones it attacked
D)a and b

Question 19

Which of the following is not true about rheumatoid arthritis? In addition to chronic inflammation,rheumatoid arthritis produces _____.

A)pain
B)joint damage
C)muscle damage
D)disability

Question 20

MATCHING
Match the following drugs with their drug classes.
a.interleukin antagonist
b.NSAID
c.tumor necrosis factor inhibitor
d.disease-modifying antirheumatic drug
e.antimalarial
f.immunosuppressive
g.glucocorticoid
methotrexate

Question 21

MATCHING
Match the following drugs with their drug classes.
a.interleukin antagonist
b.NSAID
c.tumor necrosis factor inhibitor
d.disease-modifying antirheumatic drug
e.antimalarial
f.immunosuppressive
g.glucocorticoid
Enbrel