Question 1

A female patient is being treated with biological response-modifying drugs.After completion of her treatment,she should be cautioned to avoid pregnancy for what time period?&#10;A)6 months&#10;B)12 months&#10;C)18 months&#10;D)24 months

Accepted Answer

Contraception should be used for up to 2 years following completion of treatment with a biological response-modifying drug.

Question 2

Which of the following is an effect of colony-stimulating factors (CSFs)?&#10;A)Multiplication of T cells&#10;B)Decreased neutrophil counts&#10;C)Increased cytotoxic activity of natural killer (NK) cells&#10;D)Stimulation of certain immune cells

Accepted Answer

CSFs prevent the decrease of neutrophil counts and stimulate certain immune cells (macrophages and granulocytes)to destroy or inhibit the growth of tumour cells and virus- or fungus-infected cells.

Question 3

Lymphokine-activated killer (LAK)cells,which multiply as a result of interleukin therapy,have which of the following effects?&#10;A)They directly inhibit deoxyribonucleic acid (DNA)and protein synthesis.&#10;B)They destroy cancer cells and ignore normal cells.&#10;C)They destroy cancer cells by destroying all types of cells.&#10;D)They prevent virus replication and prevent viruses from penetrating healthy cells.

Accepted Answer

LAK cells recognize cancer cells,ignore normal cells,and destroy the cancer cells on contact,thus avoiding the toxic effects of antineoplastic drugs.

Question 4

A patient is receiving therapy with interferons.What expected adverse effect should the nurse tell this patient about?&#10;A)Anemia&#10;B)Increased appetite&#10;C)Constipation&#10;D)Flu-like effects

Accepted Answer

Patients who receive interferon therapy may experience fatigue,flu-like effects,anorexia,dizziness,nausea,vomiting,and diarrhea,
Patients on interferons will not experience anemia,increased appetite,or constipation.

Question 5

Which of the following medications is indicated in the treatment of rheumatoid arthritis?&#10;A)thalidomide (Thalomid)&#10;B)tretinoin (Vesanoid)&#10;C)Bacillus Calmette-Gu&#233;rin (BCG) vaccine (Immuncyst)&#10;D)etanercept (Enbrel)

Accepted Answer

Etanercept is a tumour necrosis factor.(TNF)receptor antagonist and is indicated in the treatment of rheumatoid arthritis.

Question 6

Which intervention is appropriate during therapy with interferon drugs?&#10;A)Dosages given at bedtime minimize central nervous system (CNS)adverse effects.&#10;B)Fluids should be limited while patients are taking these medications.&#10;C)Oral dosing is preferred to minimize allergic reactions.&#10;D)Shake the drug vial well before drawing up a dose.

Accepted Answer

Dosages given at bedtime minimize CNS adverse effects.
Fluids should be increased during interferon therapy.Interferon is given either intramuscularly or subcutaneously.The drug vial should be swirled,not shaken.

Question 7

A patient is to take antineoplastic therapy with monoclonal antibodies such as rituximab (Rituxan).The nurse should carefully assess this patient for which condition?&#10;A)Anorexia&#10;B)Neuropathy&#10;C)Respiratory problems&#10;D)Heart failure

Accepted Answer

Monoclonal antibodies such as rituximab may cause respiratory problems.

Question 8

Which of the following is recommended for the administration of sargramostim (Leukine)?&#10;A)Roll the vial between the hands to mix.&#10;B)Reconstitute with 1 mL of sterile saline with preservatives.&#10;C)Shake the vial after reconstitution to ensure proper mixing.&#10;D)For intravenous (IV)solutions,dilute the medication in 5% dextrose solutions.

Accepted Answer

To administer sargramostim,roll the vial between the hands to mix.
Do not shake the vial after reconstitution.Dilute the medication in 0.9% NaCl for IV infusions.Reconstituting with 1 mL of sterile saline with preservatives is incorrect because normal saline (0.9% NaCl)is the solution recommended for dilution.

Question 9

Capillary leak syndrome during interleukin therapy may result in which of the following problems?&#10;A)Renal failure&#10;B)Asthma&#10;C)Ecchymosis&#10;D)Heart failure

Accepted Answer

When capillary leak syndrome occurs,the capillaries lose their ability to retain vital colloids,and these substances migrate into the surrounding tissues,resulting in massive fluid retention.As a result,heart failure,myocardial infarction,and dysrhythmias may occur.

Question 10

A patient with end-stage renal failure has been admitted to the hospital for severe anemia.She is refusing blood transfusions.Which drug will likely be used to stimulate red blood cell (RBC)production?

A)filgrastim (Neupogen)
B)Interferon
C)epoetin alfa (Eprex)
D)sargramostim (Leukine)

Accepted Answer

Epoetin alfa is a colony-stimulating factor that is responsible for erythropoiesis,or formation of RBCs.

Deck 50: Biological Responsemodifying Drugs