Deck 8: Lymphocytes

Question 1

Which of the following is a characteristic of NK cells?

A)They function in the innate immune response.
B)They are capable of antibody synthesis
C)They are made up the majority of lymphocytes in peripheral blood.
D)They phagocytize bacteria.

Answer 1

They phagocytize bacteria.

Question 2

A blood sample from a 5-month-old infant indicates a WBC count of 12.5 × 10⁹/L with 65% lymphocytes.What can you conclude from this?

A)The infant is normal.
B)The infant has an infection as indicated by the elevated WBC count.
C)The infant has a malignancy in the lymphocyte lineage.
D)There is not enough information to draw accurate conclusions.

Answer 2

The infant is normal.

Question 3

T,B,and NK lymphocytes can be differentiated by:

A)Morphology
B)Flow cytometry
C)Cytochemistry
D)Cytogenetic karyotype

Answer 3

Flow cytometry

Question 4

The commitment of a lymphocyte precursor cell to a T lymphocyte can be defined based on:

A)Rearrangement of the gene loci for the TCR
B)Rearrangement of the immunoglobulin gene
C)Presence of CD 19 and CD 10 by flow cytometry
D)Presence of TdT

Question 5

Which of the following is found on early T-cell precursors?

A)CD2
B)CD4
C)CD8
D)CD34

Question 6

Which of the following is considered the "pan-B" antigen?

A)CD4
B)CD8
C)CD19
D)CD10

Question 7

Which of the following describes the components used to construct an immunoglobulin?

A)5 heavy chains
B)2 light chains
C)5 identical heavy chains with 2 identical light chains
D)2 identical heavy chains with 2 identical light chains

Question 8

Which of the following terms describes an absolute increase in the number of lymphocytes?

A)Neutropenia
B)Eosinophilia
C)Leukocytosis
D)Lymphocytosis

Question 9

Reactive lymphocytes differ from normal lymphocytes in that the reactive form:

A)Is larger with an increase in basophilic cytoplasm,vacuoles,and scalloped cell shape
B)Has a condensed nuclear pattern with light pink cytoplasm
C)Has many granules,deep basophilic cytoplasm,and blast-like nucleus
D)Has a condensed nuclear chromatin,eccentric nucleus,and deep blue cytoplasm

Question 10

An instrument printout shows a normal WBC count with a lymphocyte count of 30%.What can be concluded from this?

A)The patient is suffering from an infection.
B)There is a normal lymphocyte concentration.
C)The patient is an infant.
D)The patient has leukemia.

Question 11

Which of the following is a characteristic of T lymphocytes?

A)Phagocytosis of bacteria
B)Antibody synthesis
C)Cytokine secretion
D)Few in number within peripheral blood

Question 12

Which of the following describes the distribution of lymphocytes within the body?

A)75% exist in peripheral blood,25% in lymph nodes and spleen
B)50% exist in the circulating pool,50% in the marginating pool
C)95% are found in the lymph nodes and spleen,5% in the peripheral blood
D)80% are short-lived,20% are long lived

Question 13

Which two CD markers are used to differentiate helper T cells and cytotoxic T cells?

A)CD1 and CD3
B)CD4 and CD8
C)CD10 and CD19
D)BCR and TCR

Question 14

A patient with infectious mononucleosis would most likely produce which of the following?

A)IgD antibodies
B)Polyclonal antibodies
C)Monoclonal antibodies
D)IgE antibodies

Question 15

Which cell line matures and differentiates upon exposure to antigen?

A)Neutrophilic
B)Basophilic
C)Monocytic
D)Lymphocytic

Question 16

Natural killer cells recognize and kill antigens with attached IgG.This mechanism is described as:

A)Phagocytosis
B)Cyanosis
C)Antibody-dependent cellular activity
D)Innate immune response

Question 17

The identity of immunoglobulins is determined by:

A)The number of B cells containing the antibody
B)The complexity of the antibody
C)The isotype of the heavy chain
D)The specificity of the variable region

Question 18

A blood sample from a 40-year-old white female has a WBC count of 10.2 × 10⁹/L and a lymphocyte percentage of 47%.What can be concluded from this?

A)The patient has both a relative and an absolute lymphocytosis.
B)The patient has only a relative lymphocytosis.
C)The patient has only an absolute lymphocytosis.
D)The relative and absolute counts are normal.

Question 19

What cell has CD8 on its surface?

A)T-helper cell
B)B cell
C)Macrophage
D)Cytotoxic T cell

Question 20

The lymphoid progenitor that gives rise to T,B,and NK lymphocytes is recognized as which of the following?

A)CFU_GM
B)CLP
C)CMP
D)CFU-T

Question 21

Compare and contrast the five isotypes of immunoglobulins.Include structure,function,and leukocyte interaction in your answer.

Question 22

List the subtypes of lymphocytes in normal adult peripheral blood from most numerous to least numerous.

Question 23

What are three defining characteristics that would help the laboratory professional differentiate between a blast and an activated lymphocyte?

Question 24

Describe the immunologic features and functions of NK cells.

Question 25

What is the difference between polyclonal antibodies and monoclonal antibodies?
List examples of disorders that generate each type of antibody in your answer.