Deck 4: Structure and Function of Hematopoietic Organs

Question 1

A diagnosis of hypersplenism is made when which conditions are met?

A)Presence of anemia, leukopenia, or thrombocytopenia
B)Cytopenia in both the peripheral blood and bone marrow, and correction of cytopenia after splenectomy
C)Anemia and cytopenia in the peripheral blood, existence of a cellular or hyperplastic bone marrow corresponding to the peripheral blood cytopenia, and splenomegaly
D)Cytopenia in both the peripheral blood and bone marrow

Answer 1

Anemia and cytopenia in the peripheral blood, existence of a cellular or hyperplastic bone marrow corresponding to the peripheral blood cytopenia, and splenomegaly

Question 2

A hyperplastic marrow can occur with which of the following?

A)Leukemia
B)Post-chemotherapy
C)Anemia
D)Oxygen Therapy

Answer 2

Leukemia

Question 3

The process of culling and pitting occurs in the spleen's:

A)Germinal centers.
B)Follicles.
C)Vascular sinuses.
D)Red pulp cords.

Answer 3

Red pulp cords.

Question 4

Acute blood loss can cause bone marrow hyperplasia.What factor will determine the ultimate effect of this pathologic state?

A)Ineffective hematopoiesis
B)Severity of the blood loss
C)Severity and duration of the blood loss
D)Bone marrow activity

Question 5

The primary site of hematopoiesis in an adult is:

A)Bone marrow.
B)Spleen.
C)Liver.
D)Lymph node.

Question 6

What could be the cause of an enlarged lymph node?

A)Bone marrow tumor
B)Infection
C)Allergic reaction
D)Sluggish blood flow

Question 7

Hematopoiesis in the bone marrow is chiefly controlled by which of the following?

A)The amount of fat present
B)Stromal components
C)Vasculature
D)Number of osteoblasts present

Question 8

The spleenic architecture includes the largest collection in the body of which two cells?

A)Erythrocytes and platelets
B)Lymphocytes and platelets
C)Erythrocytes and lymphocytes
D)Lymphocytes and macrophages

Question 9

At what point during fetal development does the bone marrow become the primary organ of hematopoiesis?

A)3 months' gestation
B)14 days' gestation
C)Birth
D)6 months' gestation

Question 10

Which of the following sets of organs has the capability of extramedullary hematopoiesis?

A)Thymus and lymph nodes
B)Thymus and bone marrow
C)Liver and spleen
D)Liver and bone marrow

Question 11

Peyer's patches are an example of:

A)Primary lymphoid tissue.
B)Secondary lymphoid tissue.
C)Splenic tissue.
D)Medullary tissue.

Question 12

A characteristic which defines a tissue as primary vs.secondary lymphoid tissue is:

A)Presence of activated cells in primary and resting cells in secondary lymphoid tissue.
B)Quantity of cells in each.
C)T cells in primary and B cells in secondary tissue.
D)Ability of the lymphoid cells to respond to antigens.

Question 13

What is the primary hematopoietic function of the spleen?

A)Extramedullary hematopoiesis
B)Lymphatic drainage
C)Culling and pitting
D)T cell maturation

Question 14

Splenomegaly as a result of bone marrow failure is indicative of:

A)Liver disease.
B)An accelerated immune response.
C)Extramedullary hematopoiesis.
D)Nuclear asynchrony.

Question 15

In cases where the bone marrow is compromised, hematopoiesis can resume in other organs.What is this phenomenon called, and what organs have this ability?

A)Hematopoiesis; lymph node and spleen
B)Extramedullary hematopoiesis; liver and spleen
C)Nuclear asynchrony; thymus and spleen
D)Diapedesis; blood vessels and brain

Question 16

The primary site of hematopoiesis in a 4-month-old maturing fetus is:

A)Liver.
B)Spleen.
C)Bone marrow.
D)Lymph node.

Question 17

Which of the following could cause lymphadenopathy?

A)Inflammation
B)Infection
C)Tumor
D)All of the above

Question 18

The first sign of erythroid development in an embryo occurs in:

A)Yolk sac.
B)AGM.
C)Liver.
D)Lymph node.

Question 19

All of the following contribute to a diagnosis of hypersplenism except:

A)Cytopenia in the peripheral blood.
B)Hyperplastic marrow.
C)Hepatomegaly.
D)Splenomegaly.

Question 20

Where in the body does maturation of T lymphocytes take place?

A)Lymph node
B)Bone marrow
C)Spleen
D)Thymus

Question 21

The primary sites lymphoid tissue includes:

A)Bone marrow, spleen, and liver.
B)Bone marrow, thymus, and liver.
C)Thymus, spleen, and lymph nodes.
D)Thymus, bone marrow, and lymph nodes.

Question 22

The hematopoietic compartment of the bone marrow contains what components?

A)Connective tissue and stroma
B)Hematopoietic cells and stroma
C)Tissues and vasculature
D)Tissues and stroma

Question 23

List and explain the function of the cells in the bone marrow stroma.

Question 24

Where are plasma cells located in the lymph node?

A)Cortex
B)Medulla
C)Germinal centers
D)Peripheral zone

Question 25

Explain how the bone marrow receives nutrients to survive.

Question 26

What feature separates primary from secondary lymphoid tissue?

A)Primary lymph tissue can replace secondary.
B)Primary lymphoid tissue is necessary to the secondary lymphoid tissue process.
C)Immunocompetent T and B cells are found only in secondary lymphoid tissue.
D)Immunocompetent T and B cells are found only in primary lymphoid tissue.

Question 27

Hypersplenism associated with compensatory hypertrophy of the spleen is associated with:

A)Neoplasms where malignant cells occupy much of the splenic space.
B)Congestive heart failure.
C)Liver cirrhosis with portal hypertension.
D)Infection and inflammatory diseases.

Question 28

What would you expect to see on microscopic examination of a stained blood smear if the patient has had a splenectomy and why?

Question 29

Which of the following is considered a MALT tissue?

A)Lymph node
B)Thymus
C)Tonsils
D)Bone marrow

Question 30

Predict the size of the thymus in a mature adult in comparison with an infant thymus.

A)The adult thymus will be the same size as the infant thymus.
B)The adult thymus will be larger than the infant thymus.
C)The adult thymus will be smaller than the infant thymus.
D)It cannot be determined.

Question 31

Normal proliferation of hematopoietic cells in adulthood takes place at what location?

A)Peripheral blood
B)Bone marrow
C)Stroma
D)Liver

Question 32

Track the path of maturation of the T lymphocyte.

Question 33

List four causes of a hyperplastic marrow.

Question 34

Primitive erythropoiesis in the yolk sac is important to what process?

A)Transportation of oxygen to developing tissue
B)Development of immunity
C)Liver development
D)Cellular differentiation