Question 1

Telithromycin is of the class:&#10;A) Ketolides&#10;B) Tetracyclines&#10;C) Penicillins&#10;D) Macrolides&#10;E) Fluoroquinolones

Accepted Answer

The ketolides represent a new class of antibiotics within the macrolide-lincosamide-streptogramin B family. Ketolides are semisynthetic derivatives of erythromycin that inhibit protein synthesis via interaction with the 50S ribosomal subunit. Activity against macrolide-resistant respiratory tract pathogens is maintained in ketolides, which also demonstrate excellent activity against atypical respiratory pathogens.

Question 2

Which of the following antimicrobial agents are bacteriostatic?&#10;A) Streptomycin&#10;B) Tetracycline&#10;C) Penicillin&#10;D) Mupirocin&#10;E) Ciprofloxacin

Accepted Answer

The tetracycline class of drugs is bacteriostatic. The others listed are bacteriocidal.

Question 3

The aminoglycoside class of antibiotics:&#10;A) Are bacteriostatic&#10;B) Includes ciprofloxacin&#10;C) Are ineffective against anaerobic bacteria&#10;D) Have a wide therapeutic window&#10;E) Are most often used as oral preparations

Accepted Answer

Aminoglycosides are ineffective against anaerobic organisms. The therapeutic index is narrow for this bactericidal class.

Deck 47: Inhibitors of Bacterial Ribosomal Actions