Question 1

This compound acts as an immunosuppressive drug via a DNA alkylating mechanism:&#10;A) Mycophenolate mofetil&#10;B) Tacrolimus&#10;C) Dexamethasone&#10;D) Infliximab&#10;E) Cyclophosphamide

Accepted Answer

Cyclophosphamide is an alkylating agent that crosslinks DNA, leading to cell death. It is commonly used as an immunosuppressive drug in the treatment of autoimmune disorders and as a chemotherapy agent for cancer.

Question 2

?Which of the following effectively treats relapsing forms of multiple sclerosis, thereby decreasing the frequency of clinical exacerbations and delaying physical disability?&#10;A) INF-&#945;&#10;B) INF-&#946;&#10;C) INF-&#947;&#10;D) IL-2&#10;E) IL-11

Accepted Answer

INF-β is the most effective treatment option for relapsing forms of multiple sclerosis. It has been shown to decrease the frequency of clinical exacerbations and delay physical disability in patients with multiple sclerosis. The other options (INF-α, INF-γ, IL-2, IL-11) have not been shown to be as effective for this purpose.

Question 3

Which of the following medications typically enhances immunologic activity?&#10;A) Glatiramer&#10;B) Methotrexate&#10;C) Cyclosporine&#10;D) Tacrolimus&#10;E) Sargramostim

Accepted Answer

Also known as "granulocyte-macrophage colony-stimulating factor" (GM-CSF), sargramostim enhances immunologic activity in patients suffering from deficiencies of these types of leukocyte.

Question 4

Over the first 24 hours of glucocorticoid therapy, which group of leukocytes increases in number?&#10;A) Neutrophils&#10;B) Eosinophils&#10;C) Macrophages&#10;D) Basophils&#10;E) Lymphocytes

Accepted Answer

Glucocorticoids increase neutrophil count via enhanced release from the bone marrow.

Deck 6: Antibodies and Biological Products