Deck 12: Hematologic Drugs

Question 1

Tissue plasminogen activator (tPA)drugs are given at the time of a ________ to dissolve a blood clot that has already formed.

A) myocardial infarction
B) stroke
C) pulmonary embolism
D) all of the above

Answer 1

all of the above

Question 2

Heparin is composed of large molecules that are not easily absorbed.Only about ________ of a dose actually exerts a therapeutic effect.

A) 0 to 10 percent
B) 20 to 30 percent
C) 40 to 50 percent
D) 50 to 60 percent

Answer 2

20 to 30 percent

Question 3

________ drugs bind to fibrin strands in the clot,convert plasminogen in the clot to plasmin (fibrinolysin),an enzyme that breaks apart fibrin and the clot.

A) Anticoagulant
B) Platelet aggregation inhibitor
C) Factor Xa inhibitor
D) Thrombolytic

Answer 3

Thrombolytic

Question 4

Hemophiliac patients are given ________.

A) units of whole blood
B) blood products (plasma, packed red blood cells)
C) clotting factors
D) all of the above

Question 5

All of the following are platelet aggregation inhibitor drugs,EXCEPT ________.

A) aspirin (Bayer, Ecotrin)
B) apixaban (Eliquis)
C) ticlopidine (Ticlid)
D) dipyridamole (Persantine)

Question 6

The first prescription anticoagulant drug available was ________.

A) folic acid
B) heparin
C) thrombin inhibitor drugs
D) warfarin

Question 7

Warfarin (Coumadin,Jantoven)is ________.

A) measured in milligrams
B) given orally
C) given intravenously
D) all of the above

Question 8

While she was in the hospital,Renee Waters was receiving subcutaneous heparin administered by a nurse.Now that she is being discharged home,the physician has switched her to what other drug?

A) an intravenous anticoagulant drug
B) intravenous heparin
C) an oral anticoagulant drug
D) oral heparin

Question 9

Some platelet aggregation inhibitor drugs block a receptor (glycoprotein IIb/IIIA)on platelets,and this prevents fibrinogen (clotting factor I)from binding to ________.

A) heparin
B) plasminogen (clotting factor II)
C) its receptor
D) vitamin K

Question 10

The platelet aggregation inhibitor drug dipyridamole (Persantine)is given along with other anticoagulant drugs to preventing platelets from ________.

A) adhering to artificial heart valves
B) forming blood clots after a myocardial infarction
C) causing anemia
D) inhibiting vitamin K

Question 11

The formation of many clotting factors is dependent on the presence of ________.

A) fibrin
B) plasminogen
C) thrombin
D) vitamin K

Question 12

All of the generic drugs that have ________ or iron in their name are iron supplements that are used to treat iron deficiency anemia.

A) aggregation
B) inhibitor
C) enzyme
D) ferrous

Question 13

All of the following drugs are able to dissolve a blood clot,EXCEPT ________.

A) darbepoetin alfa (Aranesp)
B) alteplase (Activase, Cathflo Activase)
C) reteplase (Retavase)
D) tenecteplase (TNKase)

Question 14

Blood coagulates to form a blood clot through a complex series of steps involving all of the following substances,EXCEPT ________.

A) clotting factors
B) platelets
C) white blood cells
D) thromboplastin

Question 15

Anticoagulant drugs are used to ________ a blood clot.

A) dissolve
B) enhance
C) prevent
D) treat

Question 16

Cathflo Activase is used to ________.

A) break up a clot that has formed in a urinary catheter
B) break up a clot that has formed in a central venous catheter or intravenous line
C) prevent a clot from forming in a central line
D) to do hemodialysis

Question 17

All of the following statements about protamine sulfate are TRUE?

A) Protamine sulfate is a low molecular weight heparin drug.
B) Protamine sulfate is used to treat a heparin overdose.
C) Protamine sulfate is used to treat anemia.
D) Protamine sulfate is an anticoagulant drug.

Question 18

Anemia can be due to insufficient amounts of all of the following,EXCEPT ________.

A) folic acid
B) iron
C) thrombin
D) vitamin B₁₂

Question 19

Heparin is always measured in ________.

A) grains
B) milligrams
C) milliliters
D) units

Question 20

One cause of anemia is due to a decrease in the ________ in the blood.

A) amount of vitamin K
B) number of clotting factors
C) number of red blood cells
D) volume of blood

Question 21

Besides being an antiplatelet drug,aspirin has other effects that include ________.

A) relieving pain
B) reducing fever
C) reducing inflammation
D) all of the above

Question 22

Which of the following is an example of the drug effect of antagonism?

A) changing from intravenous heparin in the hospital to an oral anticoagulant drug upon discharge home
B) giving a vitamin K drug to a newborn after birth to prevent hemorrhagic disease
C) taking an anticoagulant drug with a meal of leafy green vegetables
D) all of the above

Question 23

The abbreviation LMWH is associated with the drug ________.

A) rivaroxaban (Xarelto)
B) ferrous sulfate
C) factor VIII
D) heparin

Question 24

The generic platelet aggregation inhibitor drug clopidogrel is related to the well-known trade name drug ________.

A) Trental
B) Eliquis
C) Plavix
D) Coumadin

Question 25

Heparin inhibits clotting factor X in the liver,which stops the series of steps needed to form a blood clot.

Question 26

Heparin can only be given subcutaneously or intravenously.

Question 27

The ending ________ is common to generic name heparin and low molecular weight heparin drugs.

A) -rudin
B) -parin
C) -ase
D) all of the above

Question 28

Patients taking warfarin (Coumadin,Jantoven)for long-term anticoagulant drug therapy need to be sure they do not eat too much of which kinds of foods?

A) leafy green vegetables
B) beef liver
C) soybeans, soy milk, and tofu
D) all of the above

Question 29

All of the following are low molecular weight heparin drugs,EXCEPT ________.

A) heparin
B) tinzaparin (Innohep)
C) dalteparin (Fragmin)
D) enoxaparin (Lovenox)

Question 30

Which of the following is true of phytonadione (Mephyton)?

A) It is a vitamin K drug.
B) It is used to treat patients with an overdose of anticoagulant drug.
C) It is used to prevent hemorrhagic disease of the newborn.
D) all of the above

Question 31

All of the following are thrombin inhibitor drugs,EXCEPT ________.

A) apixaban (Eliquis)
B) bivalirudin (Angiomax)
C) desirudin (Ipravask)
D) lepirudin (Refludan)

Question 32

Hemophilia A is ________.

A) the most common type of hemophilia
B) caused by a lack of folic acid to build red blood cells
C) caused by the lack of clotting factor VIII
D) A and C

Question 33

Platelet aggregation inhibitor drugs prevent platelets from binding to the site of injury or from clumping together to begin the formation of a clot.

Question 34

In the drugs ferrous fumarate (Ferro-Sequels and ferrous gluconate (Fergon),the word ferrous tells you that these drugs contain ________.

A) folic acid
B) iron
C) thrombin
D) erythropoietin

Question 35

Anemia can be caused by all of the following,EXCEPT ________.

A) a lack of vitamin K
B) radiation or chemotherapy drugs that damage the bone marrow
C) blood loss due to trauma or hemophilia
D) increased destruction of red blood cells

Question 36

The liver produces clotting factors I through VIII.

Question 37

Which of the following statements about low molecular weight heparins is FALSE?

A) Low molecular weight heparins are prepared from cows' or pigs' intestines.
B) Some low molecular weight heparins are measured in units and some are measured in milligrams.
C) Low molecular weight heparins have a larger molecular size than heparin.
D) Low molecular weight heparins were created from the original heparin molecule.

Question 38

A platelet aggregation inhibitor drug would be given in all of the following situations,EXCEPT ________.

A) to prevent hemorrhagic disease after a newborn's birth
B) to prevent a blood clot after a myocardial infarction or stroke
C) to prevent a blood clot during angioplasty or cardiac valve surgery
D) to treat patients with acute coronary syndrome

Question 39

All of the following anticoagulant drugs can be given orally EXCEPT ________.

A) heparin
B) warfarin (Coumadin, Jantoven)
C) aspirin
D) clopidogrel (Plavix)

Question 40

Platelet aggregation inhibitor drugs are classified under the larger category of anticoagulant drugs.

Question 41

The chemical symbol for iron is ________.

Question 42

Hemophilia is an inherited genetic abnormality that causes a deficiency of a specific clotting factor.

Question 43

Darbepoetin alfa,epoetin alfa,and epoetin beta are erythropoietin-like drugs created with recombinant DNA technology.

Question 44

The abbreviation tPA stands for ________.

Question 45

Factor Xa inhibitor drugs exert their main effect on thrombin or platelets.

Question 46

Thrombin inhibitor drugs bind to receptors on both circulating thrombin and thrombin already incorporated in a blood clot.

Question 47

The abbreviation DVT stands for ________.

Question 48

Protamine sulfate,a heparin antagonist drug,is used to treat heparin overdose or to reverse the effect of heparin given during surgery.

Question 49

Platelets stick to damaged tissue to form clumps,and this process is known as platelet ________.

Question 50

The drug Coagulin-B is the actual cellular gene that directs the liver to produce clotting factor IX.

Question 51

The ending ________ (which means enzyme)is common to both the generic and trade names of thrombolytic drugs.

Question 52

Factor Xa inhibitor drugs are used to prevent blood clots in patients undergoing joint replacement surgery or abdominal surgery.

Question 53

Thrombolytic enzyme drugs revolutionized the treatment of myocardial infarction and stroke because they were the first drugs that could actually dissolve a clot.

Question 54

Anticoagulant drugs are given during hemodialysis for patients with chronic kidney failure.

Question 55

The anticoagulant drug warfarin (Coumadin,Jantoven)can dissolve clots that have already formed.

Question 56

A saline or heparin lock is a device that provides immediate intravenous access for administering intravenous drugs without the need to have intravenous fluids running continuously.

Question 57

Aspirin prolongs the clotting time by inhibiting thromboxane,a substance in the blood that causes platelet aggregation.

Question 58

The anticoagulant drug warfarin blocks vitamin C to keep the liver from producing clotting factors.

Question 59

Anticoagulant drugs can prevent blood clots from forming,prevent blood clots from enlarging,and are effective in dissolving blood clots once they have formed.

Question 60

The tPA drugs can ________ (break apart)a blood clot once it has formed.

Question 61

Describe the five different ways that different anticoagulant drugs work to prevent a blood clot from forming.

Question 62

Anemia is a decrease in the number of ________ blood cells (erythrocytes).

Question 63

The ending -rudin is common to generic ________ inhibitor drugs.

Question 64

Discuss what foods cause an antagonist drug-food interaction in patients taking warfarin (Coumadin,Jantoven).What one food causes a synergism drug-food interaction?

Question 65

Match the drug names in Column 1 with their drug category in Column 2.

A)over-the-counter iron supplement
B)tissue plasminogen activator drug
C)erythropoietin-like drug for anemia
D)factor Xa inhibitor drug
E)platelet aggregation inhibitor drug
F)thrombin inhibitor drug
G)warfarin
H)low molecular weight heparin drug
I)drug used to treat hemophilia
J)combination aspirin and platelet aggregation inhibitor drug
1)clopidogrel (Plavix)
2)ferrous sulfate
3)Aggrenox
4)bivalirudin (Angiomax)
5)Coumadin
6)enoxaparin (Lovenox)
7)epoetin alfa (Epogen,Procrit)
8)fondaparinux (Arixtra)
9)reteplase (Retavase)
"10)factor VIIa (NovoSeven)

Question 66

A drug-food interaction in which the food decreases the therapeutic effect of the drug is known as ________.

Question 67

The most well-known antiplatelet drug that is inexpensive and can be purchased over-the-counter is the drug ________.