Deck 17: Antiparkinson Drugs

Question 1

High doses of rasagiline will produce adverse effects through inhibition of

A) COMT
B) Dopamine reuptake
C) MAO-A
D) MAO-B

Answer 1

MAO-A

Question 2

Stalevo is a triple combination medication containing all of the following except

A) Bromocriptine
B) Levodopa
C) Carbidopa
D) Entacapone

Answer 2

Bromocriptine

Question 3

Carbidopa enhances the action of levodopa by

A) Inhibiting conversion of levodopa to dopamine in the basal ganglia
B) Inhibiting conversion of levodopa to dopamine in the periphery
C) Promoting conversion of levodopa to dopamine in the basal ganglia
D) Promoting conversion of levodopa to dopamine in the periphery

Answer 3

Inhibiting conversion of levodopa to dopamine in the periphery

Question 4

Antipsychotic medications may _____ the effectiveness of levodopa because they _____ dopamine receptors.

A) Increase, block
B) Increase, activate
C) Decrease, block
D) Decrease, activate

Question 5

Side effects from anticholinergic drugs would include all of the following except

A) Dry mouth
B) Rapid heartbeat
C) Diarrhea
D) Mydriasis

Question 6

_____ is an excitatory neurotransmitter released from the _____ area of the basal ganglia

A) Dopamine, corpus striatum
B) Acetylcholine, corpus striatum
C) Dopamine, substantia nigra
D) Acetylcholine, substantia nigra

Question 7

For best results,levodopa should be administered on an empty stomach

A) To maximize drug receptor binding to achieve a therapeutic effect
B) To minimize plasma protein binding interferences
C) To enhance absorption in the small intestines
D) To decrease interference with amino acid transporters in the brain

Question 8

Dopamine administration is not an effective method to treat Parkinsonism because

A) Dopamine is quickly metabolized to an inactive compound in the liver
B) Dopamine is too large to be absorbed by the intestines
C) Dopamine is too large to cross the blood brain barrier
D) Dopamine is quickly inactivated in the blood through enzymatic activity

Question 9

The main feature in Parkinson's disease is the accelerated loss of

A) Cholinergic neurons
B) Dopamine neurons
C) Serotonin neurons
D) Norepinephrine neurons

Question 10

A patient with Parkinson's disease who may be mobile one minute and immobile the next is probably experiencing

A) An overdose of levodopa
B) The on-off phenomenon
C) Dyskinesias
D) Livido reticularis

Question 11

The addition of carbidopa to levodopa is beneficial because it _____ the amount of dopamine being produced in the periphery and decreases the _____ seen with higher levels of levodopa.

A) Decreases, side effects
B) Increases, side effects
C) Maintains, toxic effects
D) Increases, toxic effects

Question 12

Well controlled body movements are achieved from a balance between _____ and _____.

A) Dopamine and serotonin
B) Dopamine and norepinephrine
C) Acetylcholine and dopamine
D) Acetylcholine and norepinephrine

Question 13

The use of which medication for Parkinson's disease is associated with livido reticularis?

A) Biperiden
B) Bromocriptine
C) Benztropine
D) Amantadine

Question 14

Inhibition of all of the following enzymes are important in increasing brain levels of dopamine except

A) DOPA decarboxylase
B) COMT
C) MAO-B
D) MAO-A

Question 15

Levodopa use is delayed in the beginning stages of Parkinson's disease.

A) To avoid drug-food interactions that may occur
B) To avoid having to use multiple medications
C) To avoid tolerance to levodopa over time
D) To avoid the development of movement disorders that develop over time

Question 16

The earliest symptoms of Parkinson's disease are _____ and _____

A) Vertigo and forgetfulness
B) Vertigo and maintaining balance
C) Tremor and maintaining balance
D) Tremor and muscular rigidity

Question 17

All of the following are advantages of dopamine receptor agonists over levodopa except

A) Better able to cross blood brain barrier
B) Longer duration of action
C) Lower incidence of dyskinesias
D) Less incidence of on-off phenomenon

Question 18

A reduction in tremor and muscular rigidity would be directly accomplished with

A) Amantadine
B) Anticholinergic drug
C) COMT inhibitor
D) Dopamine agonist

Question 19

Levodopa crosses the blood brain barrier through _____ which is normally specific for _____

A) Transporters, amino acids
B) Transporters, glucose
C) Ligand-gated ion channels, sodium
D) Ligand-gated ion channels, calcium

Question 20

Symptoms of Parkinson's disease include all of the following except

A) Hypertension
B) Sweating
C) Salivation
D) Urinary disturbances