Question 1

When completing a pedigree,the nurse knows to use the symbol g (blue square)to denote which of the following?&#10;A) Unknown sex,normal&#10;B) Normal male&#10;C) Female heterozygote&#10;D) Affected male

Accepted Answer

The symbol g (blue square) is used to denote an affected male in a pedigree.

Question 2

On average,what percentage of children in a family will be affected with the mutated gene in an autosomal recessive trait?&#10;A) 0%&#10;B) 25%&#10;C) 50%&#10;D) 100%

Accepted Answer

In an autosomal recessive trait, both parents must carry a copy of the mutated gene for a child to be affected. Each parent will pass on one copy of the gene to the child, and with each pregnancy, there is a 25% chance that the child will inherit two copies of the mutated gene and be affected by the trait. Therefore, the average percentage of children affected with the mutated gene in an autosomal recessive trait is 25%.

Question 3

When counselling parents about hemophilia A,an X-linked recessive trait,which of the following would be the basis for the nurse's response related to offspring?&#10;A) Daughters will not be affected with the trait or be carriers.&#10;B) Sons will not be affected with the trait or be carriers.&#10;C) Fifty percent of sons will be normal,and 50% will be affected with the trait.&#10;D) Fifty percent of daughters will be normal,and 50% will be affected with the trait.

Accepted Answer

DHemophilia A is an X-linked recessive disorder. This means that males, having only one X chromosome, will express the disease if they inherit the affected X chromosome, while females, having two X chromosomes, are carriers if they inherit one affected X chromosome. For a female carrier, there is a 50% chance that her sons will inherit the affected X chromosome and be affected by hemophilia A, and a 50% chance that her daughters will inherit the affected X chromosome and be carriers (but not show symptoms due to the presence of a normal X chromosome). Therefore, both options C and D correctly describe the inheritance pattern for hemophilia A.

Question 4

The nurse is participating in a clinical trial involving in vitro gene therapy in the treatment of a patient with adenosine deaminase (ADA)deficiency.What should the nurse explain to the patient is involved in this method of gene therapy?

A) Direct instillation of modified viruses carrying the desired genes into the patient
B) Direct microinjection of DNA into cells that have been removed from the body and reinfused
C) Removal of lung cells from the body,which are altered genetically and reinfused into the patient's blood
D) Removal of cells from the body,which are exposed to modified viruses containing desired genes and reinfusion of the cells back into the body

Accepted Answer

The answer of The nurse is participating in a clinical...

Question 5

What is the name given to a family tree that contains the genetic information and disorders of the family?&#10;A) Genome&#10;B) Hereditary&#10;C) Phenotype&#10;D) Pedigree

Accepted Answer

A pedigree is a diagrammatic representation of a family tree that's used to record and analyze the inheritance of certain traits or disorders within a family. It's an important tool in genetic counseling and can provide information about the probability of certain disorders or traits being passed down to future generations.

Question 6

A young woman's mother has been diagnosed with BRCA gene-associated breast cancer,an autosomal dominant genetic disorder.She asks the nurse about the inheritance patterns of this disorder.On what knowledge will the nurse base the response to this young woman?

A) Most affected offspring of autosomal dominant disorders are males.
B) The young woman's mother had unaffected parents who were heterozygous for the gene.
C) The young woman has a 50% chance of having the mutated gene if her mother is heterozygous.
D) Daughters of women who are heterozygotic with an autosomal dominant disorder are usually carriers of the gene.

Accepted Answer

Autosomal dominant disorders follow a 50/50 inheritance pattern. If the mother is heterozygous for the mutated gene, she has one copy of the mutated gene and one copy of the normal gene. Each of her children has a 50% chance of inheriting the mutated gene.

Question 7

A pregnant woman has asked the nurse when the best time is to undergo chorionic villus sampling.The nurse's best response is which of the following statements?&#10;A) Any time before the tenth week of gestation&#10;B) Between the eleventh and twelfth week of gestation&#10;C) Between the twenty-fourth and twenty-sixth week of gestation&#10;D) Any time during the second trimester of pregnancy

Accepted Answer

Chorionic villus sampling (CVS) is a procedure performed between the eleventh and twelfth week of gestation, and involves removal of a small sample of tissue (chorionic villi) from the placenta. This procedure is usually recommended for women who have an increased risk of having a baby with a chromosomal or genetic abnormality. CVS is not typically performed later in pregnancy (such as during the second trimester) because the placenta may have moved away from the cervix, making the procedure more difficult and risky.

Deck 15: Genetics