Deck 21: Bone Marrow Failure

Question 1

The red cell morphology associated with aplastic anemia is:

A) Normocytic normochromic with no polychromasia
B) Normocytic normochromic with marked polychromasia
C) Microcytic hypochromic with marked polychromasia
D) Microcytic normochromic with no polychromasia

Answer 1

Normocytic normochromic with no polychromasia

Question 2

Which of the following would be an unusual bone marrow finding in aplastic anemia?

A) Predominance of lymphocytes, plasma cells, and mast cells
B) Hypocellular
C) Increased megakaryocytes
D) Increased fat

Answer 2

Increased megakaryocytes

Question 3

Paroxysmal nocturnal hemoglobinuria has a high degree of association with which one of the following disorders?

A) Aplastic anemia
B) Fanconi anemia
C) Diamond-Blackfan anemia
D) CDA

Answer 3

Aplastic anemia

Question 4

What surface antigen on cells identifies them as a hematopoietic stem cell?

A) CD8
B) CD34
C) CD55
D) CD59

Question 5

Diepoxybutane causes chromosomal breakage in which of the following disorders?

A) Acquired aplastic anemia
B) Fanconi anemia
C) Diamond-Blackfan anemia
D) CDA

Question 6

What distinguishes PRCAs such as Diamond-Blackfan syndrome from aplastic anemia?

A) Peripheral red blood count
B) Number of erythroid stem cells in the bone marrow
C) Normal cellularity of myeloid cells
D) Red cell indices

Question 7

Which of the following is most useful for considering the diagnosis of bone marrow failure?

A) A hemoglobin concentration of 11 g/dL
B) An absolute neutrophil count of less than 0.5*10³/dL
C) A hypercellular bone marrow
D) Abnormal platelet function tests

Question 8

Which of the following is a feature of type II congenital dyserythropoietic anemia type II (CDA II)?

A) Giant, multinucleated red cell precursors
B) Microcytic red cells
C) Positive sucrose hemolysis test
D) Negative acidified serum test (Ham test)

Question 9

Which of the following patients fits the typical patient demographics for aplastic anemia?

A) Infant
B) A 65-year-old adult
C) A 45-year-old adult
D) A 7-year-old child

Question 10

Normal bone marrow cells being replaced with malignant cells is called:

A) Diamond-Blackfan anemia
B) CDA II
C) PRCA
D) Myelophthisic anemia

Question 11

What is the treatment of choice for a patient older than 40 years old with aplastic anemia?

A) Hematopoietic stem cell transplant
B) Antibiotic agents
C) Antithymocyte globulin (ATG)
D) Erythropoietin

Question 12

Bone marrow failure causes pancytopenia:

A) In the peripheral blood only
B) In the bone marrow only
C) In both the bone marrow and the peripheral blood
D) In the bone marrow, peripheral blood, and spleen

Question 13

Which of the following is an inherited disorder with pancytopenia, malformed kidneys, and mental deficiency?

A) Myelodysplasia
B) Fanconi anemia
C) Diamond-Blackfan anemia
D) Secondary aplastic anemia

Question 14

The cause of acquired idiopathic aplastic anemia is:

A) Epstein-Barr virus
B) Chemicals such as benzene
C) Radiation
D) Unknown

Question 15

The anemia associated with severe kidney disease is caused primarily by:

A) Damage to stem cells by urea
B) Replacement of bone marrow cells with fat
C) Deficiency of erythropoietin
D) Bleeding into the urine

Question 16

What is the treatment of choice for long-term survival for patients younger than 40 years old with aplastic anemia?

A) Blood transfusion
B) Growth factors
C) Antibiotic agents
D) Hematopoietic stem cell transplant

Question 17

Pancytopenia is a term that means :

A) Decrease in red cells, white cells, and platelets
B) Increase in red and white cells
C) Decrease in any two blood cell lines
D) Increase in white cells and platelets