Deck 12: Leukocyte Development, Kinetics, and Functions

Question 1

Lymphocytes become transformed when they are:

A) Being stimulated by an antigen
B) Undergoing mitosis
C) Dying
D) Moving to secondary lymphoid tissues

Answer 1

Being stimulated by an antigen

Question 2

Which cell is capable of phagocytosis and antigen processing?

A) Band neutrophil
B) Segmented neutrophil
C) Macrophage
D) Lymphocyte

Answer 2

Macrophage

Question 3

What is the last granulocyte in the maturation sequence able to undergo mitosis?

A) Myeloblast
B) Promyelocyte
C) Myelocyte
D) Band

Answer 3

Myelocyte

Question 4

Which of the following cells is described as a large cell with abundant cytoplasm containing minute granules, lacy chromatin, and an indented or curved nucleus?

A) Monocyte
B) Macrophage
C) Lymphocyte
D) Basophil

Question 5

What is the earliest stage of maturation where a neutrophil can be distinguished from an eosinophil?

A) Myeloblast
B) CFU-GEMM
C) Metamyelocyte
D) Myelocyte

Question 6

Select the correct maturation sequence for granulocytes starting with youngest.

A) Promyelocyte, myeloblast, metamyelocyte, myelocyte, segmented
B) Myeloblast, promyelocyte, myelocyte, metamyelocyte, band, segmented
C) Segmented, band, metamyelocyte, myelocyte, promyelocyte, myeloblast
D) CFU-GEMM, promyelocyte, metamyelocyte, myelocyte, segmented

Question 7

What directs the mitosis and maturation action of progenitor neutrophil cells in the bone marrow?

A) Erythropoietin
B) The number of stem cells
C) The number of mature cells in the peripheral circulation
D) Colony-stimulating cytokines

Question 8

What pools of leukocytes are included in the typical white blood count?

A) All cells inside the blood vessel
B) Only cells freely circulating
C) Only cells marginating against the vessel wall
D) All leukocytes in the body

Question 9

What is the primary function of leukocytes as a whole?

A) Make antibodies
B) Engulf bacteria
C) Kill parasites
D) Defend body from nonself agents

Question 10

A segmented neutrophil performs all of the following except:

A) Chemotaxis
B) Phagocytosis
C) Mitosis
D) Pinocytosis

Question 11

B cells and T cells are subgroups of what cell type?

A) Monocytes
B) Lymphocytes
C) Macrophages
D) Plasma cells

Question 12

What is the earliest morphologically identifiable cell in the granulocyte maturation sequence?

A) Pluripotent stem cell
B) Colony-forming unit-granulocyte, erythrocyte, monocyte, and megakaryocyte (CFU-GEMM)
C) Myeloblast
D) Myelocyte

Question 13

What pool of cells is the first to arrive when extra granulocytes are needed in the tissues?

A) Those that are marginating
B) Those that are freely circulating
C) Those from the bone marrow
D) Those from the lymph nodes

Question 14

Allergies are associated with an increase of which type of granulocyte?

A) Promyelocytes
B) Band neutrophils
C) Segmented neutrophils
D) Eosinophils

Question 15

A cell having a round nucleus with delicate chromatin, prominent nucleoli, and scant basophilic cytoplasm with a possible rare azurophilic granule is an accurate description of a:

A) Myeloblast
B) Myelocyte
C) Metamyelocyte
D) Band

Question 16

Which of the following neutrophils is capable of chemotaxis?

A) Stem cell
B) Progenitor cell
C) Myelocyte
D) Band

Question 17

Which of the following is a feature of a normal segmented neutrophil?

A) Basophilic cytoplasm
B) Round nucleus with fine chromatin
C) Small pink-lilac granules
D) Prominent primary granules

Question 18

Which cells are responsible for antibody production?

A) Macrophages
B) Monocytes
C) Neutrophils
D) Plasma cells

Question 19

Which cells are normally produced in multiple sites including the bone marrow, thymus, and spleen?

A) Monocytes
B) Lymphocytes
C) Eosinophils
D) Basophils

Question 20

Which of the following has the most controversial morphologic identification system?

A) Progenitor cells
B) Stem cells
C) Promyelocytes
D) Bands

Question 21

What substances in segmented neutrophils are important for intracellular killing of bacteria?

A) Alkaline phosphatase and halides
B) Myeloperoxidase and superoxide
C) Collagenase and hydrogen peroxide
D) Acid phosphatase and anions

Question 22

CD34 is an antigen found on which one of the following cells?

A) Myeloblast
B) Segmented neutrophil
C) Eosinophil
D) Lymphocyte

Question 23

Why is the bone marrow storage pool of granulocytes so large compared with the total number found in peripheral blood?

A) They prefer bone marrow to peripheral blood.
B) They can be quickly released when needed to fight bacterial infection.
C) It enhances their ability to function.
D) It prolongs their life span in circulation.