Deck 25: Treatment of Coagulation Disorders and Hyperlipidemia

Question 1

Oral anticoagulants such as warfarin (Coumadin)decrease the production of several clotting factors in the liver by interfering with the regeneration of:

A)tissue thromboplastin.
B)tissue plasminogen activator.
C)vitamin K.
D)vitamin D.
E)vitamin C.

Answer 1

vitamin K.

Question 2

All of the following drugs will inhibit platelet-induced clots EXCEPT:

A)adenosine diphosphate (ADP)receptor blockers such as clopidogrel (Plavix)and ticlopidine (Ticlid).
B)glycoprotein (GP)IIb-IIIa receptor blockers such as abciximab (ReoPro)and eptifibatide (Integrilin).
C)antigout drugs such as sulfinpyrazone (Anturane).
D)acetaminophen products (Tylenol).
E)aspirin.

Answer 2

acetaminophen products (Tylenol).

Question 3

Because of its ability to inhibit platelet activity,aspirin is used to prevent:

A)myocardial infarction.
B)ischemic stroke.
C)hemorrhagic stroke.
D)all of the above
E)A and B

Answer 3

A and B

Question 4

A patient is having a heart attack due to the sudden formation of an arterial thrombus in his coronary artery.To break up the clot and save the patient's life,the best drug to use is:

A)a low-molecular weight heparin (e.g. ,enoxaparin [Lovenox]).
B)a fibrinolytic drug (e.g. ,streptokinase [Streptase] or tPA [Activase]).
C)a fibrinolysis inhibitor (e.g. ,aminocaproic acid [Amicar]).
D)warfarin (Coumadin).
E)vitamin K.

Question 5

Drug management in hemophilia consists of giving drugs that:

A)inhibit thrombin formation.
B)inhibit vitamin K activity.
C)increase fibrinolysin activity.
D)inhibit platelet function.
E)none of the above;treatment consists of administering the missing clotting factor(s).

Question 6

Patients who develop muscle pain and weakness when taking drugs that lower lipids such as atorvastatin (Lipitor)and simvastatin (Zocor):

A)should continue on the lipid lowering drugs because these muscle symptoms are usually not severe.
B)should continue on the lipid lowering drugs,but resolve the muscle pain through strenuous resistance exercises.
C)should continue on the lipid lowering drugs,but take an analgesic such as aspirin to control the pain.
D)should be removed immediately from the drug because these symptoms may represent potentially serious myopathies.
E)none of the above;these drugs are not associated with muscle pain or weakness

Question 7

In a patient with acute deep vein thrombosis (DVT),anticoagulant therapy is typically initiated with _____ to achieve rapid control of clotting,and then switched over to _____ for long-term management or prevention of DVT.

A)heparin;oral anticoagulants
B)oral anticoagulants;thrombin
C)thrombin;tissue plasminogen activators
D)tissue plasminogen activators;fibrinolysis inhibitors
E)oral anticoagulants;heparin

Question 8

Low molecular weight heparins such as enoxaparin (Lovenox)are often preferred to traditional (unfractionated)heparin because low molecular weight heparins:

A)can be administered subcutaneously.
B)usually do not need to be administered as frequently as traditional heparin.
C)provide more predictable anticoagulant effects.
D)all of the above
E)none of the above

Question 9

Statin drugs,such atorvastatin (Lipitor)and simvastatin (Zocor)inhibit the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)reductase enzyme,thereby ______ the production of ______.

A)increasing;cholesterol
B)decreasing;cholesterol
C)increasing;low-density lipoproteins
D)decreasing;high-density lipoproteins
E)increasing;triglycerides

Question 10

Thrombolytic drugs may be helpful in treating an acute cerebrovascular accident (stroke)if:

A)they are administered 8 to 10 hours after the onset of symptoms.
B)they are administered orally.
C)the stroke is ischemic in nature.
D)all of the above
E)A and B