A Patient's Husband States, "I've Noticed That My Wife Doesn't

A patient's husband states, "I've noticed that my wife doesn't sleep well anymore and sometimes can't find the right words when we're talking." Which is the most appropriate response by the nurse?

A) "How long have you noticed these changes?"
B) "Does anyone in your family have Alzheimer's disease?"
C) "These are common changes associated with age."
D) "Do you think your spouse is depressed?"