Pyridine typically undergoes electrophilic aromatic substitution ________ rapidly than benzene, and its preferred site of substitution is the ________ - position.
A) more; 2
B) more; 3
C) more; 4
D) less; 2
E) less; 3

Question

Quizplus · Accepted Answer

Pyridine undergoes electrophilic aromatic substitution less rapidly than benzene due to the electron-withdrawing effect of the nitrogen atom, which decreases the electron density in the ring and makes it less reactive towards electrophiles. The preferred site of substitution is the 3-position, as the nitrogen atom exerts a strong electron-withdrawing effect through the sigma bond, making the 2- and 4-positions less favorable for substitution.

Pyridine Typically Undergoes Electrophilic Aromatic Substitution ________ Rapidly Than Benzene