In the addition of an electrophile to acetophenone, which of the following best describes the expected mode of reaction?
A) The o,p-positions are most activated to attack by the electrophile.
B) The m-positions are most activated to attack by the electrophile.
C) The o,p-positions are most deactivated to attack by the electrophile.
D) The m-positions are most deactivated to attack by the electrophile.
E) All positions (o, m, and p) are equally activated to attack by the electrophile.

Question

Quizplus · Accepted Answer

The carbonyl group in acetophenone is an electron-withdrawing group, which deactivates the o,p-positions towards electrophilic attack, making them less reactive compared to the m-position.

In the Addition of an Electrophile to Acetophenone, Which of the Following