Which reagents would you use for the following reaction?

Question

Quizplus · Accepted Answer

The reaction likely involves deprotonation of an alcohol to form the corresponding alkoxide ion followed by nucleophilic substitution on an alkyl halide. Sodium methoxide (NaOMe) is a strong base that can deprotonate alcohols to form alkoxide ions, so choice C is a possibility. However, the reaction may be more efficient in an aprotic solvent like acetonitrile, which will not solvate the alkoxide ion as effectively as water. Choice B is a possibility in this case. Additionally, NaOMe can be more reactive in acetonitrile due to the greater solubility of the reagent in the solvent. Therefore, choice D, NaOMe in acetonitrile, is the best choice for this reaction. Methanol alone would not be a suitable reagent for the reaction.

Which Reagents Would You Use for the Following Reaction