A Client Receiving Antineoplastic Agents in the Treatment of Lung

A client receiving antineoplastic agents in the treatment of lung cancer has been told that treatment options are limited. What is the reason that lung cancer cells have a decreased sensitivity to antineoplastic drugs?

A) Have a very erratic cell cycle, and there is little difference between the number of replicating and resting cells.
B) Grow for a long time before detection and are therefore less sensitive to antineoplastic agents.
C) Grow in a high-oxygen environment and are therefore not very sensitive to antineoplastic agents.
D) Have a low growth fraction, so there is little difference between the number of replicating and resting cells.